3 Aryloxy 3 Substituted Propanamines

Abstract: Present invention relates to novel 3-aryloxy 3-substituted propanamines of formula I, method of preparing the same and to their use in inhibiting serotonin and norepinephrine reuptake. wherein A is a phenyl which is optionally substituted with up to five substituents; a 1- or 2- naphthyl which is unsubstituted or substituted; a 5-membered heteroaryl radical which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 0- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl, or substituted phenyl and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen; a 2-benzimidazolyl optionally unsubstituted or substituted; and RI and R2 are each independently hydrogen, C1-6-alkyl, C3-7-cycloalkyl, C3-6-cycloalkyl C1-3- alkyl; or R1 and R2 may together form a C5-7-carbocyclic ring containing 0-2 hetero atoms such as N, O, or S and a salt thereof with a pharmaceutically acceptable acid. Compounds of formula I (I-A: R=4-CF3, R1=H, R2=CH3, A=4-fluorophenyl), I-B: R=4-CF3, R1=H, R2=CH3, A=4-methylphenyl, I-C: R=4-CF3, R1=H, R2=CH3, A=4-methoxyphenyl) are found to be better than the antidepressant drug fluoxetine.

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