Abstract: The present invention relates to a method for clarifying, screening, sifting, separating, and sorting substances of pharmaceutical interest using an ultrasonic vibrosifter technology. The present invention provides an excellent process which comprises of applying an ultrasonic frequency to a mechanical sieve for clarifying, screening, sifting, separating, filtering, grading or sorting the substances of pharmaceutical interest which are difficult to sift, excessively dry, waxy, low melting, electrostatically charged, fluffy or having uneven particle size distribution.