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A Process For Preparation Of Etomidate
Abstract: The present invention disclosed a process for the preparation of etomidate in which the R-(+)-phenylethylamine is reacted with ethyl chloroacetate in absence of a solvent to give R-(+)-N-[(ethoxycarbonyl)methyl]-l-phenylethylamine, which is formylated to give R-(+)-(N-formyl-N-[(ethoxycarbonyl)methyl]-l-phenylethylamine. This is further C-formylatedto give R-(+)-ethyl-2-[formy(l-phenylethyl)amino]-3-hydroxyacrylate . The obtained compound is cyclized to obtain R-(+)-l-(l-phenylethyl)-2-mercapto-5-(ethoxycarbonyl)imidazoleand this is further desulferisedin presence of hydrogen peroxide, water and a solvent to obtain R-(+)-etomidate.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
12 December 2011
Publication Number
03/2012
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
SEQUENT SCIENTIFIC LIMITED
STAR-II, OPP. TO INDIAN INSTITUTE OF MANAGEMENT, BANNERGHATTA ROAD, BANGALORE-560076,KARNATKA, INDIA
Inventors
1. MANJATHURU, MAHALINGA
C/O SEQUENT SCIENTIFIC LIMITED 120 A & B, INDUSTRIAL AREA, BAIKAMPADY, MANGALORE-575011, KARNATKA, INDIA
2. MAYEKAR, ANIL NARAYAN
C/O SEQUENT SCIENTIFIC LIMITED 120 A & B, INDUSTRIAL AREA, BAIKAMPADY, MANGALORE-575011, KARNATKA, INDIA
3. DERAMBALA, YOGEESH
C/O SEQUENT SCIENTIFIC LIMITED 120 A & B, INDUSTRIAL AREA, BAIKAMPADY, MANGALORE-575011, KARNATKA, INDIA
4. VASUDEVA, PEJAKALA KAKRANNAYA
C/O SEQUENT SCIENTIFIC LIMITED 120 A & B, INDUSTRIAL AREA, BAIKAMPADY, MANGALORE-575011, KARNATKA, INDIA
5. ARULMOLI, THANGAVEL
C/O SEQUENT SCIENTIFIC LIMITED 120 A & B, INDUSTRIAL AREA, BAIKAMPADY, MANGALORE-575011, KARNATKA, INDIA
Specification
Field of Invention
The present invention relates to a process for preparing the ethyl-1-[(1 R)-(+)-l-phenylethyl]-lH-imidazole-5-carboxylate, commonly known as R-(+)-etomidate, having the formula I:
Background of the Invention
R-(+)-etomidate is a carboxylated imidazole derivative that has anesthetic and amnestic properties. It is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia and for sedation for short procedures such as reduction of dislocated joints and cardioversion.
Etomidate was disclosed for the first time in US patent3,354,173.This patent describes a process for the preparation of etomidate by reacting
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 4309-CHE-2011 FORM-3 12-12-2011.pdf | 2011-12-12 |
| 2 | 4309-CHE-2011 FORM-2 12-12-2011.pdf | 2011-12-12 |
| 3 | 4309-CHE-2011 FORM-1 12-12-2011.pdf | 2011-12-12 |
| 4 | 4309-CHE-2011 DRAWING 12-12-2011.pdf | 2011-12-12 |
| 5 | 4309-CHE-2011 DESCRIPTION(COMPLETE) 12-12-2011.pdf | 2011-12-12 |
| 6 | 4309-CHE-2011 CORRESPONDENCE 12-12-2011.pdf | 2011-12-12 |
| 7 | 4309-CHE-2011 CLAIMS 12-12-2011.pdf | 2011-12-12 |
| 8 | 4309-CHE-2011 ABSTRACT 12-12-2011.pdf | 2011-12-12 |
| 9 | 4309-CHE-2011 FORM-1 06-01-2012.pdf | 2012-01-06 |
| 10 | 4309-CHE-2011 CORRESPONDENCE OTHERS 06-01-2012.pdf | 2012-01-06 |
| 11 | 4309-CHE-2011 FORM-9 12-01-2012.pdf | 2012-01-12 |
| 12 | 4309-CHE-2011 CORRESPONDENCE OTHERS 12-01-2012.pdf | 2012-01-12 |
| 13 | 4309-CHE-2011-Form 18-111115.pdf | 2016-04-13 |
| 14 | 4309-CHE-2011-FER.pdf | 2018-07-10 |
| 15 | 4309-CHE-2011-AbandonedLetter.pdf | 2019-01-16 |
Search Strategy
| 1 | Searchstrategy4309_10-07-2018.pdf |