This invention relates to a synergistic growth promoting composition. The composition produced by this process is particularly but not exclusively useful in promoting growth and building up resistance against illness in infants and children.
Proteins are essential constituents of living cells and play a very important role in the metabolism of living organisms. Structural substances like hair, horns, cartilage, tendons and the like are made of proteins. Proteins are complex nitrogenous substances consisting mainly of amino acid residues. It is noticed that a great variety of proteins can be synthesized from a small number of amino acids depending upon the molecular weight and the amino acid sequencing of the proteins. Amino acids are therefore, the building blocks of proteins. Animal and vegetable protein forming a part of food intake is biologically degraded into amino acids from which body proteins are synthesized during metabolic changes. It has been observed that out of the 23 amino acids vital for body growth and protein synthesis, eight amino acids are not produced in the body. The need for directly supplying these essential amino acids has been established. Protein requirements are more in growing children. Collagen present in the connective tissues, bones and cartilage is a selero protein and the eight essential amino acids form part of this protein chain. Vitamin C is also essential for the formation of inter cellular collagen. Daily supplement of vitamin C is found necessary as it is water soluble in nature and gets eliminated from the system. The therapeutic use of Vitamin C in large doses for increasing body resistance and immunity has been fully established. A combination of the eight essential amino acids and Vitamin C is found to have synergestic properties each complementing the other. Thus Collagen and other protein synthesis is enhanced and the body becomes more resistant to infections. This combination is found ideal for growing children as Collagen synthesis is enhanced by administering the composition to infants and children.

This invention relates to a synergestic growth promoting composition which comprises a blend of the compounds listed herein - under in the range specified there -against with pharmaceutically acceptable adjuvants and excipients:
L Threonine 0.63 to 1.05 mg
L Valine 1 to 1.69 mg
L Methonine 1.4 to 2.3 mg
L Isoleucine 0.88 to 1.48 mg
L Leucine 2.8 to 4.5 mg
L Phenyl alanine 0.75 to 1.25 mg
L Tryptophan 0.75 to 1.25 mg
L Lysine hydrochloride 3.75 to 6.25 mg
Vitamin C 75 mg to 125 mg.
The composition may contain flavouring and colouring agents in addition to the conventional excipients. A liquid composition is preferred for easy administration to infants and children. Antioxidants like cysteine may also be included for added process advantage and stability of the product. Some of the preferred adjuvants are sodium meta bisulphate, Disodium edetate, Thiourea, Methyl Parahydroxy benzoate Sodium, Propyl Parahydroxy benzoate Sodium, Bronopol TR which is a preservative. Sorbitol, Glycerine, Liquid glucose, Caramel, Sodium Hydroxide, Sweet Orange Flavour and American icecream soda flavour.
Amino acids and vitamin C are dissolved in sorbitol or water and the other adjuvants and flavours are added to adjust to pH of 2.8 to 3.2. Stabilizers and/or preservatives known in the pharmaceutical industry may also be added for increased shelf Ufe.

It is to be understood that obvious equivalents and alterations known to persons skilled in the art fall within the scope of this invention.
The copending applications
(1) 185/MAS/95 is directed to "A synergestic rejuvenating and revitalising pharmaceutical composition comprising a blend of the compounds listed hereunder in the range specified thereagainst with known pharmaceutically acceptable adjuvants or excipients.
L Leucine 13 to 23 mg
L Iso leucine 4.5 to 7.5 mg
L Lysine hydrochloride 19 to 31 mg
L Phenyl alanine 3.5 to 6.5 mg
L Threonine 3 to 5 mg
L Valine 5 to 8 mg
L Tryptophane 3.5 to 6.5 mg
DL Methionine 13 to 23 mg
5 Hydroxy anthranilic acid Hcl 0.15 to 0.25 mg
Vitamin A acetate 2000 to 3000 lU
Vitamin D3 150 lU to 250 lU
Vitamin B1 Mononitrate 3.5 to 6.5 mg
Vitamin B2 2 to 4 mg
Niacinamide 19 to 31 mg
Vitamin B6 Hcl 1.2 to 2.6 mg
Folic acid 0.2 to 0.9 mg
Calcium pantothenate 3.6 to 6.5 mg
Vitamin B12 1.0 to 3.1 meg

Vitamin C 20 to 50 mg
Vitamin E 1 to 9 lU
186/MAS/95 is directed to "A pharmaceutical composition, for enhancing
iron assimilation and haemoglobin synthesis comprising a blend of the
compounds listed hereunder in the range specified thereagainst with known
adjuvants and/or excipients.
Ferrous Fumarate 115 to 185 mg
L Histidine hydrochloride 3 to 5 mg
L Lysine hydrochloride 19 to 31 mg
Glycine 7.5 to 12.5 mg
Vitamin Bi mono nitrate 3.75 to 6.25
Riboflavin 2.25 to 3.75 mg
Vitamin Bg hydrochloride 1.2 to 1.8 mg
Vitamin B12 1.9 to 3.1 meg
Folic Acid 0.38 to 0.62 mg
Ascorbic acid 30 to 50 mg".
187/MAS/95 relates to "A synergistic amino acid composition effective in
utilizing excess nitrogen for protein synthesis comprising a blend of the
compounds listed herein under in the range specified thereagainst with
known pharmaceutically acceptable adjuvants and/or excipients.
L-Isoleucine 150 to 250 mg
L-Leucine 240 to 400 mg
L-Lysine Hydrochloride 220 to 370 mg
L-Methionine 240 to 400 mg
L-Phenylalanine 240 to 400 mg
L-Threonine 110 to 181 mg

L-Tryptophan 54 to 90 mg
L-Valine 175 to 270 mg
L-Histidine Hydrochloride 160 to 270 mg".
189/MAS/95 relates to "An improved purgative composition effective in maintaining electrolyte balance of body fluids comprising a blend of 46 to 74 gms polyethylene glycol, 1.1 to 1.8 gm of sodium chloride, 0.56 to 0.92 gm of potassium chloride, 1.25 to 2.1 gm of sodium bicarbonate and 4.2 to 7 gm of sodium sulphate".

WE CLAIM:
A synergestic growth promoting composition comprising a blend of the compounds listed herein below in the range specified thereagainst with pharmaceutically acceptable adjuvants, and/or excipients.
L Threonine 0.63 to 1.05 mg
L Valine 1 to 1.69 mg
L Methonine 1.4 to 2.3 mg
L Isoleucine 0.88 to 1.48 mg
L Leucine 2.8 to 4.5 mg
L Phenyl alanine 0.75 to 1.25 mg
L Tryptophan 0.75 to 1.25 mg
L Lysine hydrochloride 3.75 to 6.25 mg
Vitamin C 75 mg to 125 mg".
The composition as claimed in claim 1 containing flavouring and sweetening agents like sugar.
The composition as claimed in claims 1 and 2 having a pH of 2.8 to 3.2.
The composition as claimed in any of the above claims containing antioxidants like cysteine and sweeteners like liquid glucose.