Abstract: A twin action antipityrosporal shampoo comprising concomitant actives ketoconazole and zinc pyrithione in combination with pharmaceutically acceptable excipients and a method of making the same. The shampoo comprises ketoconazole upto 2% by weight and zinc pyrithione upto 1% by weight.The method comprises mixing ketoconazole upto 2% by weight and zinc pyrithione upto 1% by weight pharmaceutically acceptable excipients at 60- 70 C