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An Improved Process For The Preparation Nebivolol Hydrochloride
Abstract: The present invention provides an improved process for the synthesis of Nebivolol and its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). Formula I Invention involves one pot synthesis of Nebivolol from epoxy monomer, which proceeds stereo specifically, in high yield, without isolation of benzylated Nebivolol intermediate or its purification and does not require an additional purification of final compound.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
08 September 2008
Publication Number
11/2010
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
CADILA PHARMACEUTICALS LTD
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD,
Inventors
1. KHAMAR BAKULESH MAFATLAL
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
2. THAKOR INDRAJIT
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
3. PATEL MAHESH
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
4. JADAV KALPESH
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
5. PARIKH ANKUR
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
6. JOSHI ATUL CHHOTALAL
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
7. PONNAIAH RAVI
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
8. MODI INDRAVADAN AMBALAL
CADILA PHARMACEUTICALS LTD.,
CADILA CORPORATE CAMPUS,
SARKHEJ-DHOLKA ROAD,
BHAT, AHMEDABAD-382210,
Specification
FORM 2
THE PATENTS ACT, 1970 (39 of 1970)
PROVISIONAL SPECIFICATION / COMPLETE SPECIFICATION (See section 10 and rule 13)
1. TITLE OF THE INVENTION
AN IMPROVED PROCESS FOR THE PREPARATION OF NEBIVOLOL HYDROCHLORIDE
2. APPLICANT(S)
(a) NAME
(b) NATIONALITY
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1888-MUM-2008-ABSTRACT(23-7-2009).pdf | 2018-08-09 |
| 1 | 1888-MUM-2008-FORM 3(18-10-2011).pdf | 2011-10-18 |
| 2 | 1888-mum-2008-abstract.doc | 2018-08-09 |
| 2 | 1888-MUM-2008-FORM 18(18-10-2011).pdf | 2011-10-18 |
| 3 | 1888-MUM-2008-CORRESPONDENCE(18-10-2011).pdf | 2011-10-18 |
| 3 | 1888-mum-2008-abstract.pdf | 2018-08-09 |
| 4 | 1888-MUM-2008-FORM 3(12-11-2014).pdf | 2014-11-12 |
| 4 | 1888-MUM-2008-CLAIMS(23-7-2009).pdf | 2018-08-09 |
| 5 | 1888-MUM-2008-CORRESPONDENCE(17-7-2009).pdf | 2018-08-09 |
| 5 | 1888-MUM-2008-CORRESPONDENCE(12-11-2014).pdf | 2014-11-12 |
| 6 | 1888-MUM-2008_EXAMREPORT.pdf | 2018-08-09 |
| 6 | 1888-MUM-2008-CORRESPONDENCE(IPO)-(DECISION)-(23-6-2016).pdf | 2018-08-09 |
| 7 | 1888-MUM-2008-REPLY TO EXAMINATION REPORT(8-6-2015).pdf | 2018-08-09 |
| 7 | 1888-MUM-2008-CORRESPONDENCE(IPO)-(FER)-(22-7-2014).pdf | 2018-08-09 |
| 8 | 1888-mum-2008-power of attorney.pdf | 2018-08-09 |
| 8 | 1888-mum-2008-correspondence.pdf | 2018-08-09 |
| 9 | 1888-MUM-2008-DESCRIPTION(COMPLETE)-(23-7-2009).pdf | 2018-08-09 |
| 9 | 1888-MUM-2008-GENERAL POWER OF ATTORNEY(23-7-2009).pdf | 2018-08-09 |
| 10 | 1888-MUM-2008-FORM 5(23-7-2009).pdf | 2018-08-09 |
| 11 | 1888-mum-2008-description(provisional).pdf | 2018-08-09 |
| 11 | 1888-mum-2008-form 3.pdf | 2018-08-09 |
| 12 | 1888-MUM-2008-FORM 1(23-7-2009).pdf | 2018-08-09 |
| 12 | 1888-MUM-2008-FORM 3(23-7-2009).pdf | 2018-08-09 |
| 13 | 1888-mum-2008-form 1.pdf | 2018-08-09 |
| 13 | 1888-mum-2008-form 2.pdf | 2018-08-09 |
| 14 | 1888-mum-2008-form 2(23-7-2009).pdf | 2018-08-09 |
| 15 | 1888-MUM-2008-FORM 2(TITLE PAGE)-(23-7-2009).pdf | 2018-08-09 |
| 15 | 1888-mum-2008-form 2(title page).pdf | 2018-08-09 |
| 16 | 1888-MUM-2008-FORM 2(TITLE PAGE)-(23-7-2009).pdf | 2018-08-09 |
| 16 | 1888-mum-2008-form 2(title page).pdf | 2018-08-09 |
| 17 | 1888-mum-2008-form 2(23-7-2009).pdf | 2018-08-09 |
| 18 | 1888-mum-2008-form 2.pdf | 2018-08-09 |
| 18 | 1888-mum-2008-form 1.pdf | 2018-08-09 |
| 19 | 1888-MUM-2008-FORM 3(23-7-2009).pdf | 2018-08-09 |
| 19 | 1888-MUM-2008-FORM 1(23-7-2009).pdf | 2018-08-09 |
| 20 | 1888-mum-2008-description(provisional).pdf | 2018-08-09 |
| 20 | 1888-mum-2008-form 3.pdf | 2018-08-09 |
| 21 | 1888-MUM-2008-FORM 5(23-7-2009).pdf | 2018-08-09 |
| 22 | 1888-MUM-2008-DESCRIPTION(COMPLETE)-(23-7-2009).pdf | 2018-08-09 |
| 22 | 1888-MUM-2008-GENERAL POWER OF ATTORNEY(23-7-2009).pdf | 2018-08-09 |
| 23 | 1888-mum-2008-correspondence.pdf | 2018-08-09 |
| 23 | 1888-mum-2008-power of attorney.pdf | 2018-08-09 |
| 24 | 1888-MUM-2008-CORRESPONDENCE(IPO)-(FER)-(22-7-2014).pdf | 2018-08-09 |
| 24 | 1888-MUM-2008-REPLY TO EXAMINATION REPORT(8-6-2015).pdf | 2018-08-09 |
| 25 | 1888-MUM-2008-CORRESPONDENCE(IPO)-(DECISION)-(23-6-2016).pdf | 2018-08-09 |
| 25 | 1888-MUM-2008_EXAMREPORT.pdf | 2018-08-09 |
| 26 | 1888-MUM-2008-CORRESPONDENCE(12-11-2014).pdf | 2014-11-12 |
| 26 | 1888-MUM-2008-CORRESPONDENCE(17-7-2009).pdf | 2018-08-09 |
| 27 | 1888-MUM-2008-FORM 3(12-11-2014).pdf | 2014-11-12 |
| 27 | 1888-MUM-2008-CLAIMS(23-7-2009).pdf | 2018-08-09 |
| 28 | 1888-MUM-2008-CORRESPONDENCE(18-10-2011).pdf | 2011-10-18 |
| 28 | 1888-mum-2008-abstract.pdf | 2018-08-09 |
| 29 | 1888-MUM-2008-FORM 18(18-10-2011).pdf | 2011-10-18 |
| 30 | 1888-MUM-2008-FORM 3(18-10-2011).pdf | 2011-10-18 |
| 30 | 1888-MUM-2008-ABSTRACT(23-7-2009).pdf | 2018-08-09 |