Abstract: The present disclosure provides a composition comprising cocoa extract, and grape seed extract, which at particular w/w ratios and concentrations exhibits enhanced ability to inhibit intracellular cholesterol levels.
Claims:1. A composition comprising:
a. cocoa extract; and
b. grape seed extract;
wherein cocoa extract to grape seed extract w/w ratio in said composition is in the range of 1:0.66-1:1.5.
2. The composition as claimed in claim 1, wherein cocoa extract concentration in said composition in the range of 0.0002-0.0003%, and grape seed extract concentration in said composition in the range of 0.0002-0.0003%.
3. The composition as claimed in claim 1, wherein cocoa extract to grape seed extract w/w ratio in said composition is 1:1.
4. The composition as claimed in claim 3, wherein cocoa extract concentration in said composition is 0.00025%, and grape seed extract concentration in said composition is 0.00025%.
5. The composition as claimed in any of the claims 1-4, wherein said cocoa extract comprises at least 10 wt % theobromine with respect to cocoa extract, , at least 15 wt % total polyphenols with respect to cocoa extract, and said grape seed extract comprises at least 95 wt % proanthocyanidins with respect to grape seed extract, and at least 70 wt % total polyphenols with respect of grape seed extract.
6. The composition as claimed in any of the claims 1-5, further comprising suitable carriers, diluents, and excipients.
7. A method of preparing a composition as claimed in any of the claims 1-6.
8. A method of inhibition of intracellular cholesterol levels, said method comprising:
a. obtaining a composition as claimed in any of the claims 1-6; and
b. contacting said composition with a cell capable of intracellular cholesterol synthesis,
wherein said method inhibits intracellular cholesterol levels.
9. A composition as claimed in any of the claims 1-6 for use in preparing oral formulation to inhibit intracellular cholesterol levels.
, Description:As Attached
| # | Name | Date |
|---|---|---|
| 1 | Form 5 [14-03-2016(online)].pdf | 2016-03-14 |
| 2 | Form 3 [14-03-2016(online)].pdf | 2016-03-14 |
| 3 | Drawing [14-03-2016(online)].pdf | 2016-03-14 |
| 4 | Description(Complete) [14-03-2016(online)].pdf | 2016-03-14 |
| 5 | 201641008882-Power of Attorney-270416.pdf | 2016-07-14 |
| 6 | 201641008882-Form 1-270416.pdf | 2016-07-14 |
| 7 | 201641008882-Correspondence-F1-PA-270416.pdf | 2016-07-14 |
| 8 | 201641008882-FORM 18 [13-03-2020(online)].pdf | 2020-03-13 |
| 9 | 201641008882-FER.pdf | 2022-08-01 |
| 1 | 201641008882E_29-07-2022.pdf |