Double Stranded Oligonucleotide Compositions And Methods Relating Thereto

Abstract: The present disclosure provides double stranded oligonucleotides, compositions, and methods relating thereto. The present disclosure encompasses the recognition that structural elements of double stranded oligonucleotides, such as base sequence, chemical modifications (e.g, modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, and/or stereochemistry (e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)), and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g, RNA interference (RNAi) activity, stability, delivery, etc. The present disclosure also provides methods for treatment of diseases using provided double stranded oligonucleotide compositions, for example, in RNA interference.

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#	Name	Date
1	202217072910-STATEMENT OF UNDERTAKING (FORM 3) [16-12-2022(online)].pdf	2022-12-16
2	202217072910-Sequence Listing in txt [16-12-2022(online)].txt	2022-12-16
3	202217072910-Sequence Listing in PDF [16-12-2022(online)].pdf	2022-12-16
4	202217072910-POWER OF AUTHORITY [16-12-2022(online)].pdf	2022-12-16
5	202217072910-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [16-12-2022(online)].pdf	2022-12-16
6	202217072910-FORM 1 [16-12-2022(online)].pdf	2022-12-16
7	202217072910-DECLARATION OF INVENTORSHIP (FORM 5) [16-12-2022(online)].pdf	2022-12-16
8	202217072910-COMPLETE SPECIFICATION [16-12-2022(online)].pdf	2022-12-16
9	202217072910-Proof of Right [30-12-2022(online)].pdf	2022-12-30
10	202217072910-FORM 3 [04-05-2023(online)].pdf	2023-05-04
11	202217072910-FORM 18 [07-05-2024(online)].pdf	2024-05-07