Liver Spheroid Disease Models

Abstract: ABSTRACT LIVER SPHEROID DISEASE MODELS Disclosed is a method of inducing non-alcoholic steato-hepatitis in a multi-component liver spheroid. The method includes harvesting or reviving a cryopreserved sample of two or more distinct primary liver cell types and seeding a mixture of at least two or more distinct primary liver cell types to generate a multi-component liver spheroid. Disclosed are mono-component and multi component liver spheroid. The method further includes inducing steatosis in the multi-component liver spheroid through treatment of one or more steatosis inducers, inducing steatohepatitis in the multi-component liver spheroid through a combinatorial treatment of a mixture of the one or more steatosis inducers and one or more fibrosis inducers; and inducing fibrosis in the multi-component liver spheroid through treatment with one or more fibrosis inducers.

Patent Information

Application #

Filing Date

11 August 2022

Publication Number

07/2024

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

PANDORUM TECHNOLOGIES PRIVATE LIMITED

Center for Cellular and Molecular Platforms, National Center for Biological Sciences Campus, GKVK Post, Bellary Road, Bengaluru 560065, India

Inventors

1. BHOWMICK, Tuhin

PANDORUM TECHNOLOGIES PVT. LTD., Center for Cellular and Molecular Platforms, National Center for Biological Sciences Campus, GKVK Post, Bellary Road, Bengaluru 560065, India

2. CHANDRU, Arun

PANDORUM TECHNOLOGIES PVT. LTD., Center for Cellular and Molecular Platforms, National Center for Biological Sciences Campus, GKVK Post, Bellary Road, Bengaluru 560065, India

3. KARUNAKARAN, Wenson David Rajan

PANDORUM TECHNOLOGIES PVT. LTD., Center for Cellular and Molecular Platforms, National Center for Biological Sciences Campus, GKVK Post, Bellary Road, Bengaluru 560065, India

4. RAJENDRAN, Nisha Palaniswamy

PANDORUM TECHNOLOGIES PVT. LTD., Center for Cellular and Molecular Platforms, National Center for Biological Sciences Campus, GKVK Post, Bellary Road, Bengaluru 560065, India

Specification

DESC:LIVER SPHEROID DISEASE MODELS ,CLAIMS:AS ATTACHED

Documents

Application Documents

#	Name	Date
1	202241045831-STATEMENT OF UNDERTAKING (FORM 3) [11-08-2022(online)].pdf	2022-08-11
2	202241045831-PROVISIONAL SPECIFICATION [11-08-2022(online)].pdf	2022-08-11
3	202241045831-FORM 1 [11-08-2022(online)].pdf	2022-08-11
4	202241045831-DRAWINGS [11-08-2022(online)].pdf	2022-08-11
5	202241045831-Proof of Right [09-11-2022(online)].pdf	2022-11-09
6	202241045831-FORM-26 [09-11-2022(online)].pdf	2022-11-09
7	202241045831-Proof of Right [24-11-2022(online)].pdf	2022-11-24
8	202241045831-Request Letter-Correspondence [14-07-2023(online)].pdf	2023-07-14
9	202241045831-Power of Attorney [14-07-2023(online)].pdf	2023-07-14
10	202241045831-Form 1 (Submitted on date of filing) [14-07-2023(online)].pdf	2023-07-14
11	202241045831-Covering Letter [14-07-2023(online)].pdf	2023-07-14
12	202241045831-CERTIFIED COPIES TRANSMISSION TO IB [14-07-2023(online)].pdf	2023-07-14
13	202241045831-DRAWING [11-08-2023(online)].pdf	2023-08-11
14	202241045831-CORRESPONDENCE-OTHERS [11-08-2023(online)].pdf	2023-08-11
15	202241045831-COMPLETE SPECIFICATION [11-08-2023(online)].pdf	2023-08-11
16	202241045831-FORM 3 [09-02-2024(online)].pdf	2024-02-09