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"Methods For Enhanced Production Of Bone Morphogenetic Proteins"
Abstract: Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-3 superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 µM and if pyridoxal is present, it makes up less than 55 % of the molar concentration of vitamin B6 in the media.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
29 October 2010
Publication Number
36/2011
Publication Type
INA
Invention Field
BIO-CHEMISTRY
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2017-08-21
Renewal Date
Applicants
WYETH LLC
FIVE GIRALDA FARMS, MADISON, NEW JERSEY 07940, UNITED STATES OF AMERICA
Inventors
1. TERRY CARDOZA
1 RIVERVIEW BOULEVARD, UNIT 1-213, METHUEN, MASSACHUSETTS 01844, U.S.A.
2. DENIS DRAPEAU
55 OLD FARM ROAD, SALEM, NEW HAMPSHIRE 03079, U.S.A.
3. JOSE MANUEL GOMES
46 LITTLETON ROAD, CHELMSFORD, MASSACHUSETTS 01824, U.S.A.
4. YEN-TUNG LUAN
3 ARMAND DRIVE, CHELMSFORD, MASSACHUSETTS 01824, U.S.A.
5. GREGG NYBERG
11145 N. ELIOT COURT, WESTMINSTER, COLORADO 80234, U.S.A.
6. WENGE WANG
1 HOLLOW RIDGE ROAD, NORTH CHELMSFORD, MASSACHUSETTS 01863, U.S.A.
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 7636-delnp-2010-Correspondence Others-(16-02-2010).pdf | 2010-02-16 |
| 1 | 7636-DELNP-2010-PROOF OF ALTERATION [16-08-2023(online)].pdf | 2023-08-16 |
| 2 | 7636-DELNP-2010-Form-3-(07-01-2011).pdf | 2011-01-07 |
| 2 | 7636-DELNP-2010-RELEVANT DOCUMENTS [21-06-2022(online)].pdf | 2022-06-21 |
| 3 | 7636-DELNP-2010-Correspondence-Others-(07-01-2011).pdf | 2011-01-07 |
| 3 | 7636-delnp-2010-Correspondence-220322.pdf | 2022-03-23 |
| 4 | 7636-delnp-2010-gpa.pdf | 2011-08-20 |
| 4 | 7636-delnp-2010-GPA-220322.pdf | 2022-03-23 |
| 5 | 7636-delnp-2010-form-5.pdf | 2011-08-20 |
| 5 | 7636-DELNP-2010-FORM-26 [26-11-2021(online)].pdf | 2021-11-26 |
| 6 | 7636-DELNP-2010-RELEVANT DOCUMENTS [04-09-2021(online)].pdf | 2021-09-04 |
| 6 | 7636-delnp-2010-form-3.pdf | 2011-08-20 |
| 7 | 7636-DELNP-2010-RELEVANT DOCUMENTS [06-03-2020(online)].pdf | 2020-03-06 |
| 7 | 7636-delnp-2010-form-2.pdf | 2011-08-20 |
| 8 | 7636-DELNP-2010-RELEVANT DOCUMENTS [28-02-2020(online)].pdf | 2020-02-28 |
| 8 | 7636-delnp-2010-form-18.pdf | 2011-08-20 |
| 9 | 7636-delnp-2010-form-1.pdf | 2011-08-20 |
| 9 | 7636-DELNP-2010-FORM-26 [07-08-2019(online)].pdf | 2019-08-07 |
| 10 | 7636-delnp-2010-drawings.pdf | 2011-08-20 |
| 10 | 7636-DELNP-2010-FORM-26 [02-08-2019(online)].pdf | 2019-08-02 |
| 11 | 7636-delnp-2010-description (complete).pdf | 2011-08-20 |
| 11 | 7636-DELNP-2010-RELEVANT DOCUMENTS [05-03-2019(online)].pdf | 2019-03-05 |
| 12 | 7636-delnp-2010-correspondence-others.pdf | 2011-08-20 |
| 12 | 7636-DELNP-2010-RELEVANT DOCUMENTS [28-03-2018(online)].pdf | 2018-03-28 |
| 13 | 7636-delnp-2010-claims.pdf | 2011-08-20 |
| 13 | 7636-DELNP-2010-IntimationOfGrant21-08-2017.pdf | 2017-08-21 |
| 14 | 7636-delnp-2010-assignment.pdf | 2011-08-20 |
| 14 | 7636-DELNP-2010-PatentCertificate21-08-2017.pdf | 2017-08-21 |
| 15 | 7636-delnp-2010-abstract.pdf | 2011-08-20 |
| 15 | Written submissions and relevant documents [12-07-2017(online)].pdf | 2017-07-12 |
| 16 | 7636-delnp-2010-Form-3-(09-11-2011).pdf | 2011-11-09 |
| 16 | HEARING ADJOURNMENT [17-05-2017(online)].pdf | 2017-05-17 |
| 17 | HEARING ADJOURNMENT [18-04-2017(online)].pdf | 2017-04-18 |
| 17 | 7636-delnp-2010-Correspondence-Others-(09-11-2011).pdf | 2011-11-09 |
| 18 | 7636-DELNP-2010-GPA-(16-09-2014).pdf | 2014-09-16 |
| 18 | 7636-DELNP-2010_EXAMREPORT.pdf | 2016-06-30 |
| 19 | 7636-DELNP-2010-Correspondence-Others-(16-09-2014).pdf | 2014-09-16 |
| 19 | 7636-delnp-2010-Others Documents.pdf | 2016-02-20 |
| 20 | 7636-delnp-2010-Correspondence Others-(16-09-2014).pdf | 2014-09-16 |
| 20 | 7636-delnp-2010-PCT-105.pdf | 2016-02-20 |
| 21 | 7636-delnp-2010-PCT-202.pdf | 2016-02-20 |
| 21 | Petition Under Rule 137 [05-08-2015(online)].pdf_1.pdf | 2015-08-05 |
| 22 | 7636-delnp-2010-PCT-210.pdf | 2016-02-20 |
| 22 | Petition Under Rule 137 [05-08-2015(online)].pdf | 2015-08-05 |
| 23 | 7636-delnp-2010-PCT-220.pdf | 2016-02-20 |
| 23 | Other Document [05-08-2015(online)].pdf_2.pdf | 2015-08-05 |
| 24 | Other Document [05-08-2015(online)].pdf | 2015-08-05 |
| 24 | 7636-delnp-2010-PCT-237.pdf | 2016-02-20 |
| 25 | 7636-delnp-2010-PCT-301.pdf | 2016-02-20 |
| 25 | Examination Report Reply Recieved [05-08-2015(online)].pdf | 2015-08-05 |
| 26 | 7636-delnp-2010-PCT-304.pdf | 2016-02-20 |
| 26 | Description(Complete) [05-08-2015(online)].pdf | 2015-08-05 |
| 27 | 7636-delnp-2010-PCT-308.pdf | 2016-02-20 |
| 27 | Correspondence [05-08-2015(online)].pdf | 2015-08-05 |
| 28 | 7636-delnp-2010-PCT-311.pdf | 2016-02-20 |
| 28 | Claims [05-08-2015(online)].pdf | 2015-08-05 |
| 29 | 7636-delnp-2010-PCT-373.pdf | 2016-02-20 |
| 29 | Abstract [05-08-2015(online)].pdf | 2015-08-05 |
| 30 | 7636-delnp-2010-Drawings-(05-08-2015).pdf | 2015-08-05 |
| 30 | 7636-delnp-2010-PCT.pdf | 2016-02-20 |
| 31 | 7636-delnp-2010-Correspodence Others-(05-08-2015).pdf | 2015-08-05 |
| 32 | 7636-delnp-2010-Drawings-(05-08-2015).pdf | 2015-08-05 |
| 32 | 7636-delnp-2010-PCT.pdf | 2016-02-20 |
| 33 | 7636-delnp-2010-PCT-373.pdf | 2016-02-20 |
| 33 | Abstract [05-08-2015(online)].pdf | 2015-08-05 |
| 34 | 7636-delnp-2010-PCT-311.pdf | 2016-02-20 |
| 34 | Claims [05-08-2015(online)].pdf | 2015-08-05 |
| 35 | 7636-delnp-2010-PCT-308.pdf | 2016-02-20 |
| 35 | Correspondence [05-08-2015(online)].pdf | 2015-08-05 |
| 36 | Description(Complete) [05-08-2015(online)].pdf | 2015-08-05 |
| 36 | 7636-delnp-2010-PCT-304.pdf | 2016-02-20 |
| 37 | Examination Report Reply Recieved [05-08-2015(online)].pdf | 2015-08-05 |
| 37 | 7636-delnp-2010-PCT-301.pdf | 2016-02-20 |
| 38 | 7636-delnp-2010-PCT-237.pdf | 2016-02-20 |
| 38 | Other Document [05-08-2015(online)].pdf | 2015-08-05 |
| 39 | 7636-delnp-2010-PCT-220.pdf | 2016-02-20 |
| 39 | Other Document [05-08-2015(online)].pdf_2.pdf | 2015-08-05 |
| 40 | 7636-delnp-2010-PCT-210.pdf | 2016-02-20 |
| 40 | Petition Under Rule 137 [05-08-2015(online)].pdf | 2015-08-05 |
| 41 | 7636-delnp-2010-PCT-202.pdf | 2016-02-20 |
| 41 | Petition Under Rule 137 [05-08-2015(online)].pdf_1.pdf | 2015-08-05 |
| 42 | 7636-delnp-2010-Correspondence Others-(16-09-2014).pdf | 2014-09-16 |
| 42 | 7636-delnp-2010-PCT-105.pdf | 2016-02-20 |
| 43 | 7636-DELNP-2010-Correspondence-Others-(16-09-2014).pdf | 2014-09-16 |
| 43 | 7636-delnp-2010-Others Documents.pdf | 2016-02-20 |
| 44 | 7636-DELNP-2010-GPA-(16-09-2014).pdf | 2014-09-16 |
| 44 | 7636-DELNP-2010_EXAMREPORT.pdf | 2016-06-30 |
| 45 | 7636-delnp-2010-Correspondence-Others-(09-11-2011).pdf | 2011-11-09 |
| 45 | HEARING ADJOURNMENT [18-04-2017(online)].pdf | 2017-04-18 |
| 46 | HEARING ADJOURNMENT [17-05-2017(online)].pdf | 2017-05-17 |
| 46 | 7636-delnp-2010-Form-3-(09-11-2011).pdf | 2011-11-09 |
| 47 | 7636-delnp-2010-abstract.pdf | 2011-08-20 |
| 47 | Written submissions and relevant documents [12-07-2017(online)].pdf | 2017-07-12 |
| 48 | 7636-delnp-2010-assignment.pdf | 2011-08-20 |
| 48 | 7636-DELNP-2010-PatentCertificate21-08-2017.pdf | 2017-08-21 |
| 49 | 7636-delnp-2010-claims.pdf | 2011-08-20 |
| 49 | 7636-DELNP-2010-IntimationOfGrant21-08-2017.pdf | 2017-08-21 |
| 50 | 7636-delnp-2010-correspondence-others.pdf | 2011-08-20 |
| 50 | 7636-DELNP-2010-RELEVANT DOCUMENTS [28-03-2018(online)].pdf | 2018-03-28 |
| 51 | 7636-delnp-2010-description (complete).pdf | 2011-08-20 |
| 51 | 7636-DELNP-2010-RELEVANT DOCUMENTS [05-03-2019(online)].pdf | 2019-03-05 |
| 52 | 7636-delnp-2010-drawings.pdf | 2011-08-20 |
| 52 | 7636-DELNP-2010-FORM-26 [02-08-2019(online)].pdf | 2019-08-02 |
| 53 | 7636-delnp-2010-form-1.pdf | 2011-08-20 |
| 53 | 7636-DELNP-2010-FORM-26 [07-08-2019(online)].pdf | 2019-08-07 |
| 54 | 7636-delnp-2010-form-18.pdf | 2011-08-20 |
| 54 | 7636-DELNP-2010-RELEVANT DOCUMENTS [28-02-2020(online)].pdf | 2020-02-28 |
| 55 | 7636-DELNP-2010-RELEVANT DOCUMENTS [06-03-2020(online)].pdf | 2020-03-06 |
| 55 | 7636-delnp-2010-form-2.pdf | 2011-08-20 |
| 56 | 7636-DELNP-2010-RELEVANT DOCUMENTS [04-09-2021(online)].pdf | 2021-09-04 |
| 56 | 7636-delnp-2010-form-3.pdf | 2011-08-20 |
| 57 | 7636-delnp-2010-form-5.pdf | 2011-08-20 |
| 57 | 7636-DELNP-2010-FORM-26 [26-11-2021(online)].pdf | 2021-11-26 |
| 58 | 7636-delnp-2010-gpa.pdf | 2011-08-20 |
| 58 | 7636-delnp-2010-GPA-220322.pdf | 2022-03-23 |
| 59 | 7636-delnp-2010-Correspondence-220322.pdf | 2022-03-23 |
| 59 | 7636-DELNP-2010-Correspondence-Others-(07-01-2011).pdf | 2011-01-07 |
| 60 | 7636-DELNP-2010-Form-3-(07-01-2011).pdf | 2011-01-07 |
| 60 | 7636-DELNP-2010-RELEVANT DOCUMENTS [21-06-2022(online)].pdf | 2022-06-21 |
| 61 | 7636-delnp-2010-Correspondence Others-(16-02-2010).pdf | 2010-02-16 |
| 61 | 7636-DELNP-2010-PROOF OF ALTERATION [16-08-2023(online)].pdf | 2023-08-16 |