Methods Of Expanding Cholangiocytes

Abstract: This invention relates to the expansion of primary cholangiocytes in the form of cholangiocyte organoids (COs) using culture conditions in which canonical Wnt signalling is inhibited and non-canonical Wnt/PCP signalling is potentiated. Methods of expanding primary cholangiocytes, expanded populations of cholangiocytes and medical applications of expanded cholangiocytes are provided.

Patent Information

Application #

Filing Date

13 January 2020

Publication Number

40/2020

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

IPO@KNSPARTNERS.COM

Parent Application

Applicants

CAMBRIDGE ENTERPRISE LIMITED

The Old Schools Trinity Lane Cambridge Cambridgeshire CB2 1TN

Inventors

1. VALLIER, Ludovic

Department of Surgery Box 202, Level E9 Addenbrooke's Hospital, Hills Road Cambridge Cambridgeshire CB2 0QQ

2. HANNAN, Nicholas

Department of Surgery Box 202, Level E9 Addenbrooke's Hospital, Hills Road Cambridge Cambridgeshire CB2 0QQ

3. SAEB-PARSY, Kourosh

Department of Surgery Box 202, Level E9 Addenbrooke's Hospital, Hills Road Cambridge Cambridgeshire CB2 0QQ

4. SAMPAZIOTIS, Fotis

Department of Surgery Box 202, Level E9 Addenbrooke's Hospital, Hills Road Cambridge Cambridgeshire CB2 0QQ

Specification

Documents

Application Documents

#	Name	Date
1	202017001786-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [13-01-2020(online)].pdf	2020-01-13
2	202017001786-STATEMENT OF UNDERTAKING (FORM 3) [13-01-2020(online)].pdf	2020-01-13
3	202017001786-FORM 1 [13-01-2020(online)].pdf	2020-01-13
4	202017001786-DRAWINGS [13-01-2020(online)].pdf	2020-01-13
5	202017001786-DECLARATION OF INVENTORSHIP (FORM 5) [13-01-2020(online)].pdf	2020-01-13
6	202017001786-COMPLETE SPECIFICATION [13-01-2020(online)].pdf	2020-01-13
7	202017001786.pdf	2020-01-15
8	202017001786-FORM 3 [12-02-2020(online)].pdf	2020-02-12
9	202017001786-FORM-26 [17-02-2020(online)].pdf	2020-02-17
10	202017001786-Proof of Right [05-06-2020(online)].pdf	2020-06-05
11	202017001786-RELEVANT DOCUMENTS [13-10-2020(online)].pdf	2020-10-13
12	202017001786-FORM 13 [13-10-2020(online)].pdf	2020-10-13
13	202017001786-FORM 18 [04-06-2021(online)].pdf	2021-06-04
14	202017001786-Power of Attorney-200220.pdf	2021-10-19
15	202017001786-Correspondence-200220.pdf	2021-10-19
16	202017001786-FORM 3 [30-10-2023(online)].pdf	2023-10-30