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Mutation Analysis Using Melting Temperature And Universal Bases
Abstract: A method and an oligonucleotide probe are described for determining the presence or absence of mutant alleles in a genomic locus. The probe binds to different alleles of a target sequence with different melting temperatures (Tm). The method determines the Tm of the probe when it is hybridized to the target sequence to establish whether a variant nucleic acid such as a mutant allele is present or absent in the target sequence. There may be variants in a target sequence that are not of interest for example phenotypically silent mutations. To ensure that these variants do not influence the Tm of the probe the probe contains universal base sites where such variants of no interest occur.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
01 April 2016
Publication Number
27/2016
Publication Type
INA
Invention Field
MICRO BIOLOGY
Status
Email
iprdel@lakshmisri.com
Parent Application
Patent Number
Legal Status
Grant Date
2023-11-21
Renewal Date
Applicants
EPISTEM LIMITED
48 Grafton Street
Manchester M13 9XX
Inventors
1. COBB Ben
c/o Epistem Limited
48 Grafton Street
Manchester M13 9XX
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 201647011706-IntimationOfGrant21-11-2023.pdf | 2023-11-21 |
| 1 | Form 5 [01-04-2016(online)].pdf | 2016-04-01 |
| 2 | 201647011706-PatentCertificate21-11-2023.pdf | 2023-11-21 |
| 2 | Form 3 [01-04-2016(online)].pdf | 2016-04-01 |
| 3 | Drawing [01-04-2016(online)].pdf | 2016-04-01 |
| 3 | 201647011706-FORM 3 [07-10-2020(online)].pdf | 2020-10-07 |
| 4 | Description(Complete) [01-04-2016(online)].pdf | 2016-04-01 |
| 4 | 201647011706-FORM 3 [23-03-2020(online)].pdf | 2020-03-23 |
| 5 | 201647011706.pdf | 2016-06-08 |
| 5 | 201647011706-CLAIMS [08-01-2020(online)].pdf | 2020-01-08 |
| 6 | Form 26 [04-07-2016(online)].pdf | 2016-07-04 |
| 6 | 201647011706-DRAWING [08-01-2020(online)].pdf | 2020-01-08 |
| 7 | Other Patent Document [21-07-2016(online)].pdf | 2016-07-21 |
| 7 | 201647011706-FER_SER_REPLY [08-01-2020(online)].pdf | 2020-01-08 |
| 8 | 201647011706-Power of Attorney-110716.pdf | 2016-07-29 |
| 8 | 201647011706-OTHERS [08-01-2020(online)].pdf | 2020-01-08 |
| 9 | 201647011706-Correspondence-PA-110716.pdf | 2016-07-29 |
| 9 | 201647011706-FORM 3 [01-10-2019(online)].pdf | 2019-10-01 |
| 10 | 201647011706-FER.pdf | 2019-09-24 |
| 10 | 201647011706-Form 1-250716.pdf | 2016-08-02 |
| 11 | 201647011706-Correspondence-F1-250716.pdf | 2016-08-02 |
| 11 | 201647011706-FORM 3 [14-03-2019(online)].pdf | 2019-03-14 |
| 12 | 201647011706-FORM 3 [14-09-2018(online)].pdf | 2018-09-14 |
| 12 | Form 3 [21-09-2016(online)].pdf | 2016-09-21 |
| 13 | 201647011706-FORM 3 [09-10-2017(online)].pdf | 2017-10-09 |
| 13 | Form 3 [29-03-2017(online)].pdf | 2017-03-29 |
| 14 | Form 18 [11-07-2017(online)].pdf | 2017-07-11 |
| 15 | 201647011706-FORM 3 [09-10-2017(online)].pdf | 2017-10-09 |
| 15 | Form 3 [29-03-2017(online)].pdf | 2017-03-29 |
| 16 | 201647011706-FORM 3 [14-09-2018(online)].pdf | 2018-09-14 |
| 16 | Form 3 [21-09-2016(online)].pdf | 2016-09-21 |
| 17 | 201647011706-FORM 3 [14-03-2019(online)].pdf | 2019-03-14 |
| 17 | 201647011706-Correspondence-F1-250716.pdf | 2016-08-02 |
| 18 | 201647011706-Form 1-250716.pdf | 2016-08-02 |
| 18 | 201647011706-FER.pdf | 2019-09-24 |
| 19 | 201647011706-Correspondence-PA-110716.pdf | 2016-07-29 |
| 19 | 201647011706-FORM 3 [01-10-2019(online)].pdf | 2019-10-01 |
| 20 | 201647011706-OTHERS [08-01-2020(online)].pdf | 2020-01-08 |
| 20 | 201647011706-Power of Attorney-110716.pdf | 2016-07-29 |
| 21 | 201647011706-FER_SER_REPLY [08-01-2020(online)].pdf | 2020-01-08 |
| 21 | Other Patent Document [21-07-2016(online)].pdf | 2016-07-21 |
| 22 | 201647011706-DRAWING [08-01-2020(online)].pdf | 2020-01-08 |
| 22 | Form 26 [04-07-2016(online)].pdf | 2016-07-04 |
| 23 | 201647011706-CLAIMS [08-01-2020(online)].pdf | 2020-01-08 |
| 23 | 201647011706.pdf | 2016-06-08 |
| 24 | 201647011706-FORM 3 [23-03-2020(online)].pdf | 2020-03-23 |
| 24 | Description(Complete) [01-04-2016(online)].pdf | 2016-04-01 |
| 25 | Drawing [01-04-2016(online)].pdf | 2016-04-01 |
| 25 | 201647011706-FORM 3 [07-10-2020(online)].pdf | 2020-10-07 |
| 26 | Form 3 [01-04-2016(online)].pdf | 2016-04-01 |
| 26 | 201647011706-PatentCertificate21-11-2023.pdf | 2023-11-21 |
| 27 | Form 5 [01-04-2016(online)].pdf | 2016-04-01 |
| 27 | 201647011706-IntimationOfGrant21-11-2023.pdf | 2023-11-21 |
Search Strategy
| 1 | TotalPatent_23-09-2019.pdf |