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Pyrimidine Compounds
Abstract: Provided herein are heterocyclic compounds of the general formula (I), th~ir derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3 R4 and R5 are as described herein: Further described herein in particular are heterocyclic compounds of the formula (I) for treati~g various diseases and disorders by administering in a patient one or more TNF -<1, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-I; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-I, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).
Notices, Deadlines & Correspondence
Patent Information
Applicants
Orchid Research Laboratories Ltd
Inventors
1. GANAPAVARAPU VEERA RAHAVA SHARMA
2. GADDAM OM REDDY
3. SRIRAM RAJAGOPAL
4. UMA RAMCHANDRAN
5. SUKUNATH NARAYANAN
6. PICHIKA NAGALAKSHMI
7. VENKATESH NEMMARA VISWANATHAN
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 488-CHE-2007 FORM-3 23-09-2009.pdf | 2009-09-23 |
| 1 | 488-CHE-2007_EXAMREPORT.pdf | 2016-07-02 |
| 2 | abs-488.jpg | 2011-09-03 |
| 2 | 488-CHE-2007 AMENDED PAGES OF SPECIFICATION 23-08-2013.pdf | 2013-08-23 |
| 3 | 488-che-2007-form 1.pdf | 2011-09-03 |
| 3 | 488-CHE-2007 AMENDED CLAIMS 23-08-2013.pdf | 2013-08-23 |
| 4 | 488-CHE-2007 FORM-1 23-08-2013.pdf | 2013-08-23 |
| 4 | 488-che-2007-description(provisional).pdf | 2011-09-03 |
| 5 | 488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 23-08-2013.pdf | 2013-08-23 |
| 5 | 488-che-2005-correspodance others.pdf | 2011-09-03 |
| 6 | 488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 12-10-2012.pdf | 2012-10-12 |
| 6 | 488-CHE-2007 AMENDED PAGES OF SPECIFICATION 12-10-2012.pdf | 2012-10-12 |
| 7 | 488-CHE-2007 FORM-3 12-10-2012.pdf | 2012-10-12 |
| 7 | 488-CHE-2007 AMENDED CLAIMS 12-10-2012.pdf | 2012-10-12 |
| 8 | 488-CHE-2007 FORM-3 12-10-2012.pdf | 2012-10-12 |
| 8 | 488-CHE-2007 AMENDED CLAIMS 12-10-2012.pdf | 2012-10-12 |
| 9 | 488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 12-10-2012.pdf | 2012-10-12 |
| 9 | 488-CHE-2007 AMENDED PAGES OF SPECIFICATION 12-10-2012.pdf | 2012-10-12 |
| 10 | 488-che-2005-correspodance others.pdf | 2011-09-03 |
| 10 | 488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 23-08-2013.pdf | 2013-08-23 |
| 11 | 488-CHE-2007 FORM-1 23-08-2013.pdf | 2013-08-23 |
| 11 | 488-che-2007-description(provisional).pdf | 2011-09-03 |
| 12 | 488-che-2007-form 1.pdf | 2011-09-03 |
| 12 | 488-CHE-2007 AMENDED CLAIMS 23-08-2013.pdf | 2013-08-23 |
| 13 | abs-488.jpg | 2011-09-03 |
| 13 | 488-CHE-2007 AMENDED PAGES OF SPECIFICATION 23-08-2013.pdf | 2013-08-23 |
| 14 | 488-CHE-2007_EXAMREPORT.pdf | 2016-07-02 |
| 14 | 488-CHE-2007 FORM-3 23-09-2009.pdf | 2009-09-23 |