Abstract: The present invention relates to novel andrographolide compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing thein. The present invention more particularly relates to novel derivatives of andrographolide, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The novel compounds of andrographolide have the general formula (I), Where all symobols are defined in the specification