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Novel Cytochrome P450 Polypeptide With Increased Enzymatic Activity
Abstract: The present invention pertains to an isolated P450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to SEQ ID NO: 1 wherein said sequence comprises a threonine at position corresponding to position 225 and/or an aspartic acid mutation at position corresponding to position 289. The invention also concerns an isolated nucleic acid comprising a sequence encoding said enzyme a vector comprising said nucleic acid and a host cell containing said nucleic acid or said vector. Methods for preparing said enzyme and methods for producing steroid hormone precursors using the enzyme or the host cells featured in the invention are also provided.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
22 July 2016
Publication Number
35/2016
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
SANOFI
54 rue La Boétie
F 75008 Paris
Inventors
1. BERTIN Marine
c/o Sanofi
Patent Department
54 rue La Boétie
F 75008 Paris
2. DUMAS Bruno
c/o Sanofi
Patent Department
54 rue La Boétie
F 75008 Paris
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 201637025226-AbandonedLetter.pdf | 2024-05-17 |
| 1 | Sequence listing [22-07-2016(online)].txt | 2016-07-22 |
| 2 | 201637025226-FER.pdf | 2020-02-28 |
| 3 | Form 5 [22-07-2016(online)].pdf | 2016-07-22 |
| 3 | 201637025226-FORM 18 [28-12-2017(online)].pdf | 2017-12-28 |
| 4 | Form 3 [18-01-2017(online)].pdf | 2017-01-18 |
| 4 | Form 3 [22-07-2016(online)].pdf | 2016-07-22 |
| 5 | Form 1 [22-07-2016(online)].pdf | 2016-07-22 |
| 5 | Other Patent Document [18-01-2017(online)].pdf | 2017-01-18 |
| 6 | Other Patent Document [17-10-2016(online)].pdf | 2016-10-17 |
| 6 | Drawing [22-07-2016(online)].pdf | 2016-07-22 |
| 7 | Description(Complete) [22-07-2016(online)].pdf | 2016-07-22 |
| 8 | Other Patent Document [17-10-2016(online)].pdf | 2016-10-17 |
| 8 | Drawing [22-07-2016(online)].pdf | 2016-07-22 |
| 9 | Other Patent Document [18-01-2017(online)].pdf | 2017-01-18 |
| 9 | Form 1 [22-07-2016(online)].pdf | 2016-07-22 |
| 10 | Form 3 [18-01-2017(online)].pdf | 2017-01-18 |
| 10 | Form 3 [22-07-2016(online)].pdf | 2016-07-22 |
| 11 | 201637025226-FORM 18 [28-12-2017(online)].pdf | 2017-12-28 |
| 11 | Form 5 [22-07-2016(online)].pdf | 2016-07-22 |
| 12 | 201637025226-FER.pdf | 2020-02-28 |
| 13 | Sequence listing [22-07-2016(online)].txt | 2016-07-22 |
| 13 | 201637025226-AbandonedLetter.pdf | 2024-05-17 |
Search Strategy
| 1 | search1_26-02-2020.pdf |
| 1 | search2_26-02-2020.pdf |
| 2 | search1_26-02-2020.pdf |
| 2 | search2_26-02-2020.pdf |