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Pharmaceutical Compositions Comprising Human Antibodies To Pcsk9
Abstract: The present invention relates to Pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (PCSK9) to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9 specific antibodies or antigen binding fragments thereof and preferably by additional administration of an inhibitor of 3 hydroxy 3 methyl glutaryl CoA reductase (HMG CoA reductase). The present invention further relates to PCSK9 specific antibodies or antigen binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact. The present invention also relates to articles of manufacture comprising packaging material PCSK9 specific antibodies or antigen binding fragments thereof and a label or packaging insert indicating which groups of patients can be treated with said antibodies or fragments which groups of patients must not be treated with said antibodies or fragments and which dosage regimen should be used. The present invention further relates to methods of testing the efficacy of PCSK9 specific antibodies or antigen binding fragments thereof for the treatment of certain diseases or conditions and for the treatment of specific sub groups of patients.
Notices, Deadlines & Correspondence
Patent Information
Applicants
SANOFI
Inventors
1. HANOTIN Corinne
2. BESSAC Laurence
3. CHAUDHARI Umesh
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 6743-CHENP-2013-AbandonedLetter.pdf | 2019-07-02 |
| 1 | SEQUENCE LISTING.txt | 2013-09-17 |
| 2 | 6743-CHENP-2013-FORM 3 [03-04-2019(online)].pdf | 2019-04-03 |
| 2 | GPA.pdf | 2013-09-17 |
| 3 | FORM-5.pdf | 2013-09-17 |
| 3 | 6743-CHENP-2013-FORM 4(ii) [22-03-2019(online)].pdf | 2019-03-22 |
| 4 | FORM-3.pdf | 2013-09-17 |
| 4 | 6743-CHENP-2013-FER.pdf | 2018-09-26 |
| 5 | 6743-CHENP-2013-FORM 3 [27-03-2018(online)].pdf | 2018-03-27 |
| 5 | 4034-2013-CLAIMS.pdf | 2013-09-17 |
| 6 | 6743-CHENP-2013-FORM 3 [08-08-2017(online)].pdf | 2017-08-08 |
| 6 | 6743-CHENP-2013 FORM-3 18-02-2014.pdf | 2014-02-18 |
| 7 | 6743-CHENP-2013-Correspondence-Others-PA-180416.pdf | 2016-07-06 |
| 7 | 6743-CHENP-2013 CORRESPONDENCE OTHERS 18-02-2014.pdf | 2014-02-18 |
| 8 | DRAWINGS.pdf | 2014-08-21 |
| 8 | 6743-CHENP-2013-OTHERS-180416.pdf | 2016-07-06 |
| 9 | 6743-CHENP-2013-Power of Attorney-180416.pdf | 2016-07-06 |
| 9 | DESCRIPTION (COMPLETE).pdf | 2014-08-21 |
| 10 | ABSTRACT.pdf | 2014-08-21 |
| 10 | Assignment [15-04-2016(online)].pdf | 2016-04-15 |
| 11 | 6743-P-2013_Markedup Claims_24-03-2015.pdf | 2015-03-24 |
| 11 | Form 6 [15-04-2016(online)].pdf | 2016-04-15 |
| 12 | 6743-P-2013_Form 13_24-03-2015.pdf | 2015-03-24 |
| 12 | Power of Attorney [15-04-2016(online)].pdf | 2016-04-15 |
| 13 | 6743-CHENP-2013 FORM-13 24-03-2015.pdf | 2015-03-24 |
| 13 | 6743-P-2013_Clear Claims_24-03-2015.pdf | 2015-03-24 |
| 14 | 6743-CHENP-2013 CORRESPONDENCE OTHERS 24-03-2015.pdf | 2015-03-24 |
| 15 | 6743-CHENP-2013 FORM-13 24-03-2015.pdf | 2015-03-24 |
| 15 | 6743-P-2013_Clear Claims_24-03-2015.pdf | 2015-03-24 |
| 16 | 6743-P-2013_Form 13_24-03-2015.pdf | 2015-03-24 |
| 16 | Power of Attorney [15-04-2016(online)].pdf | 2016-04-15 |
| 17 | Form 6 [15-04-2016(online)].pdf | 2016-04-15 |
| 17 | 6743-P-2013_Markedup Claims_24-03-2015.pdf | 2015-03-24 |
| 18 | Assignment [15-04-2016(online)].pdf | 2016-04-15 |
| 18 | ABSTRACT.pdf | 2014-08-21 |
| 19 | 6743-CHENP-2013-Power of Attorney-180416.pdf | 2016-07-06 |
| 19 | DESCRIPTION (COMPLETE).pdf | 2014-08-21 |
| 20 | 6743-CHENP-2013-OTHERS-180416.pdf | 2016-07-06 |
| 20 | DRAWINGS.pdf | 2014-08-21 |
| 21 | 6743-CHENP-2013 CORRESPONDENCE OTHERS 18-02-2014.pdf | 2014-02-18 |
| 21 | 6743-CHENP-2013-Correspondence-Others-PA-180416.pdf | 2016-07-06 |
| 22 | 6743-CHENP-2013 FORM-3 18-02-2014.pdf | 2014-02-18 |
| 22 | 6743-CHENP-2013-FORM 3 [08-08-2017(online)].pdf | 2017-08-08 |
| 23 | 4034-2013-CLAIMS.pdf | 2013-09-17 |
| 23 | 6743-CHENP-2013-FORM 3 [27-03-2018(online)].pdf | 2018-03-27 |
| 24 | 6743-CHENP-2013-FER.pdf | 2018-09-26 |
| 24 | FORM-3.pdf | 2013-09-17 |
| 25 | FORM-5.pdf | 2013-09-17 |
| 25 | 6743-CHENP-2013-FORM 4(ii) [22-03-2019(online)].pdf | 2019-03-22 |
| 26 | GPA.pdf | 2013-09-17 |
| 26 | 6743-CHENP-2013-FORM 3 [03-04-2019(online)].pdf | 2019-04-03 |
| 27 | SEQUENCE LISTING.txt | 2013-09-17 |
| 27 | 6743-CHENP-2013-AbandonedLetter.pdf | 2019-07-02 |
Search Strategy
| 1 | strategy_6743_19-09-2018.pdf |