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Process For The Preparation Of Molnupiravir
Abstract: A process for the preparation of Molnupiravir, an antiviral drug under investigation for the treatment of Covid-19, is provided comprising reacting 2-3-isopropylidene cytidine with isobutyric anhydride in the presence of a base to obtain 5'-isobutyric ester having an amide impurity. Treatingthe reaction mixture with para-toluenesulphonic acid monohydrate results in acetonide deprotection giving pure isobutyric cytidine tosylate salt which is free from the amide impurity. Conversion of tosylate salt into free base and reacting with hydroxylamine gives Molnupiravir.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
23 April 2021
Publication Number
19/2021
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2022-01-04
Renewal Date
Applicants
DIVI’S LABORATORIES LTD
1—72/23(P)/DIVIS/303;Divi Towers;
Cyberhills, Gachibowli; Hyderabad -
500032, Telangana, India.
Inventors
1. Murali Krishna Prasad Divi
1—72/23(P)/DIVIS/303;Divi Towers;
Cyberhills, Gachibowli; Hyderabad -
500032, Telangana, India.
2. Mysore AswathaNarayana Rao
1—72/23(P)/DIVIS/303;Divi Towers;
Cyberhills, Gachibowli; Hyderabad -
500032, Telangana, India.
Specification
Soft Copy Attached in PDF.
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202141018775-Form2 Title Page_Complete_23-04-2021.pdf | 2021-04-23 |
| 2 | 202141018775-Form1_As Filed_23-04-2021.pdf | 2021-04-23 |
| 3 | 202141018775-Description Complete_As Filed_23-04-2021.pdf | 2021-04-23 |
| 4 | 202141018775-Correspondence_As Filed_23-04-2021.pdf | 2021-04-23 |
| 5 | 202141018775-Claims_As Filed_23-04-2021.pdf | 2021-04-23 |
| 6 | 202141018775-Abstract_As Filed_23-04-2021.pdf | 2021-04-23 |
| 7 | 202141018775-Form 9_Earlier Publication_03-05-2021.pdf | 2021-05-03 |
| 8 | 202141018775-Form 5_Declaration_03-05-2021.pdf | 2021-05-03 |
| 9 | 202141018775-Form 18_Examination Request_03-05-2021.pdf | 2021-05-03 |
| 10 | 202141018775-Correspondence_Request for Certified Copies_03-05-2021.pdf | 2021-05-03 |
| 11 | 202141018775-Marked Up Copy of Claims_Fer Reply_05-08-2021.pdf | 2021-08-05 |
| 12 | 202141018775-Form-3_Fer Reply_05-08-2021.pdf | 2021-08-05 |
| 13 | 202141018775-Examination Report Reply Recieved-05-08-2021.pdf | 2021-08-05 |
| 14 | 202141018775-Claims_Fer Reply_05-08-2021.pdf | 2021-08-05 |
| 15 | 202141018775-US(14)-HearingNotice-(HearingDate-16-11-2021).pdf | 2021-10-18 |
| 16 | 202141018775-FER.pdf | 2021-10-18 |
| 17 | 202141018775-Correspondence-08-11-2021.pdf | 2021-11-08 |
| 18 | 202141018775-Markedup Copy_Hearing Reply_22-11-2021.pdf | 2021-11-22 |
| 19 | 202141018775-Correspondence_Hearing Reply_22-11-2021.pdf | 2021-11-22 |
| 20 | 202141018775-Claims_Hearing Reply_22-11-20211.pdf | 2021-11-22 |
| 21 | 202141018775-PatentCertificate04-01-2022.pdf | 2022-01-04 |
| 22 | 202141018775-IntimationOfGrant04-01-2022.pdf | 2022-01-04 |
| 23 | 385994-Correspondence_Renewal Fee_06-03-2023.pdf | 2023-03-06 |
Search Strategy
| 1 | IntellectualPropertyIndiaE_02-06-2021.pdf |