A method of localising portable apparatus (100) in an environment the method comprising obtaining captured image data representing an image captured by an imaging device (106) associated with the portable apparatus and obtaining mesh data representing a 3 dimensional textured mesh of at least part of the environment...

A CONVENIENT AND SCALABLE SYNTHESIS OF DGJNAC 1D FROM D-GLUCURONOLACTONE IN AN OVERALL YIELD OF 20% IS PROVIDED. DGJNAC IS THE FIRST HIGHLY POTENT AND SPECIFIC COMPETITIVE INHIBITOR OF GALNACASES. DGJNAC 1D IS ALSO A COMPETITIVE INHIBITOR OF -HEXOSAMINIDASES. SYNTHESIS AND ACTIVITY OF L-DGJNAC 1L IS ALSO SHOWN. THE ...

The present application provides novel lipidomic markers for Hepatitis C and related conditions, such as hepatic fibrosis and hepatocellular carcinoma.

The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with he...

Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imaging agent, encapsulated inside the particles inside the ER lumen of the cell. The compositions can be useful for treat...

A method of localising portable apparatus (200) obtains: a stored experience data set comprising a set of connected nodes; captured location representation data provided by at least one sensor associated with the portable apparatus and a current pose estimate of the portable apparatus within the environment. The pos...