A method of expressing or improving expression levels of one or more proteins in a transgenic plant comprising inserting into the genome of said plant a DNA sequence comprising a promoter region operably linked to two or more protein encoding regions and a 3'-terminator region wherein said protein encoding regions a...

Nucleotide sequences and the expression products thereof are described for use in the production of transgenic plants. In particular polynucleotides comprising a sequence selected from those depicted in SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4 and SEQ ID No.5 are provided.

An isolated DNA construct comprising: a) a first DNA sequence comprising either an inducible promoter sequence responsive to the presence or absence of an exogenous inducer or a developmental gene promoter capable of initiating gene expression in a selected tissue or at a selected stage of development of an organism...

. A vacuum cleaner comprising a first casing housing dust separation apparatus, a second casing housing at least one filter or other component of the vacuum cleaner, and a central spine housing at least one conduit forming part of an airflow path within the vacuum cleaner, the first and second casings lying g...

YES

N/A

The use of a formulation comprising the components: a) a volatile chemical inducer; b) a polyethoxylated C10-C20 alcohol or a trisiloxane polyethoxylate and c) a diluent; for controlling expression of a target gene in an organism having a chemically- inducible gene expression cassette comprising an inducibl...

A method for producing the magnesium bis-hydrocarbyloxide, said method comprising: reacting a magnesium alkoxide of the formula : Mg(OR6)2 wherein R6 represents an alkyl radical with up to two moles of a phenol having at least one unsubstituted position ortho to the hydroxyl group.

An isolated polynucleotide comprising the sequence depicted in SEQ ID No. 33

An isolated polynucleotide comprising the sequence depicted in SEQ ID No.41

An isolated polynucleotide comprising the sequence depicted in SEQ ID No.43.

A method of producing crystal A of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid for use as therapeutic agent, said method comprising: crystallizing 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid at the start of crystallization in the presence of a composition of a mixed sol...

A fungicidal compound having the general formula (I) or a stereoisomer thereof, wherein A is CH or N, B is OCH3 or NHCH3, Rl is H, chloro or methyl an dR2 is H, fluoro, chloro or methyl.

A process for the coloration of a substrate comprising applying thereto a composition comprising a dye and a nucleophilic agent and heating and/or basifying the composition thereby joining the dye and nucleophilic agent together by the formation of covalent bonds, wherein: (i) the dye has at least one electrophili...

A dye comprising molecules which contain a nucleophilic group and an electrophilic group characterised in that (i) the molecules are capable of joining together by formation of a covalent bond between the nucleophilic group of one molecule and the electrophilic group of another molecule when the dye is heated, acidi...

A new salt of a prodrug useful in antibody directed enzyme prodrug therapy (ADEPT) is disclosed. A hydrogen iodide salt of the prodrug N-(4-[N.N-bis(2-iodoethyl)aminolphenoxycarbonyl)-L-glutarnic acid is prepared which can be obtained in crystalline form. Preparation of the crystalline form of the prodrug enables p...

Cyclic peptides of formula 1 wherein: AA1 is an L or D amino acid selected from He and Leu or amino acid analogue thereof; AA2 is an L amino acid selected from Leu or amino acid analogue thereof; AA3 is an L amino acid selected from Asp or amino acid analogue thereof containing a coarboxyl group in its side chain ;...

Improved systems for targetted enzyme prodrug therapy, especially antibody directed enzyme prodrug therapy (ADEPT), in which the enzyme used is a mutated form of a host enzyme in which the natural host enzyme, such as ribonuclease, recognises its natural substrate by an ion pair interaction and this interaction is r...

A composition comprising a first, second, third and fourth dye, each of which is of formula (1) or a salt thereof: wherein: X is a labile atom or group; A and B are each independently an optionally substituted phenylene group; one of R1 and R2 is H and the other is sulpho; one of R3 and R4 is H and the other is su...

The invention concerns quinazoline derivatives of the formula 1 wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); wherein Q1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q1 optionally bears up to 3 substituents; wherein m is 1 or 2 and each R1 may be a group such as hydroge...

This invention relates to reactive dyes, their preparation and use for the coloration of materials and to materials when coloured by the dyes. According to the present invention there is provided a dye having at least two groups each of which independently is of the formula (1):

A ptocess for preparing 4,6-dihydroxypyrimidine comprising the Abtfraol : steps (a) reacting formamide, an alkoxide of formula ROM and, at the same time or later reacting, a malonate of formula CH2(C02R2) in a solvent of formula ROH, the molar ratio of formamide:ROM: CN2(C02R2) being ...

The invention relates to sustained release formulations comprising 11-[4-[2-(2-hydroxyethoxy)ethyl]-1 -piperazinyl]dibenzo[b,f] [ 1,4]thiazepine or a pharmaceutically acceptable salt thereof, to methods of treating psychotic states and hyperactivity utilizing the sustained release formulations and to a process for p...

The use of a polycyciic aromatic ring system containing 3 or more fused rings, such as pyrene-1-sulphonic acid, for improving the dispersion and/or flocculation resistance of a particulate solid in a polar liquid medium.

The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wher...

Crystalline 11 -(4-[2-(2-hydroxyethoxy)ethyl]-l -piperazinyl)-dibenzo[b,f][1,4]thiazepine may be prepared by crystallising 11-(4-[2-(2-hydroxyethoxy)ethyl)-l-piperazinyl)-dibenzo[b,f][l,4]thiazepine from a non-aromatic solvent such as ethyl acetate, isobutyl acetate, methyl iso-butylketone or methyl tert-butyl ether...

A process for coloration of a substrate comprising applying thereto at a pH above 7 a water-soluble reactive dye comprising at least three chromophoric groups linked to a polyamine. Also claimed are dyes suitable for use in the process.

The invention relates to heterocyclic derivatives of formula (I), or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heteroc...

A compound of the formula: wherein: R is alkyl; R1 is optionally substituted phenyl, 2-oxo-tetrahydro-l(2H)-pyrimidinyl, or 2-oxo-l- piperidinyl; R2 is hydrogen, alkoxy, alkanoyloxy, alkoxycarbonyl, alkanoylamino, acyl, alkyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl where the alkyl groups are the sam...

Use of neurokinin 2 (NK2) receptor antagonists in the treatment or prevention of gastric asthma or adverse respiratory events associated with gastroesophageal reflux, including pharamceutical compositions containing the NK2 receptor antagonist and methods for making such compositions.

A process for preparing an alkyl ester of 3-(2-chloro-3, 3, 3-trifluoro-prop-l-en-yl)-2, 2-dimethylcyclopropane carboxylic acid which comprises (a) reacting the compound of formula I CF3-CXC1-CH(OH)CH2-C(CH3)2-CH2-C02R wherein X represents chlorine or bromine and R represents hydrogen or alk...

A compound having the formula wherein: R2 is hydrogen, hydroxy, alkoxy, alkanoyloxy, alkanoyl, alkoxycarbonyl, alkanoylamino, alkyl, carbamoyl, alkylcarbamoyl or di-alkylcarbamoyl; R3 is H or alkyl; R4 is independently selected from hydroxy, halo, alkoxy, alkyl, cyanoalkyl, alkenyl, alkynyl, carboxy, alkoxycarbonyl...

A compound having the formula wherein R1 is oxo, -ORa -OC(=O)Rb; or R2 is H; or R1 is -ORc and R2 is -ORd; or R1 and R2 together form -O(CH2)mO-; R3 is H or alkyl; R4, R5 and R6 are independently selected from hydroxy, cyano, nitro, trifluoromethoxy, trifluoromethyl, alkylsulfonyl, halo, alkoxy, alkyl, cyanoalkyl,...

A compound of formula (I): R2 wherein R1 represents a group of formula (A) where each of W, X, Y and Z and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom and where each R present is independently selected from hydrogen and halogen at...

The invention relates to quinazoline derivatives of the formula I:- wherein m is an integer from 1 to 2; R1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C1.3alkyl, C1-3alkoxy, C].3alkylthio, or -NR5R6 (wherein R5 and R6, which may be the same or different, each represents hydrogen or C1_3a...

Plasmids which comprise (1) an origin of replication; (2) an additional sequence required for plasmid replication or preferably a gene giving a selective advantage; and (3) two expression cassettes each of which are located between (1) and (2) but are separated by (1) and (2) from each other; and which are f...

A process for the manufacture of a coloured aromatic polyester textile material or fibre blend thereof comprises applying to the aromatic polyester textile material a dispersion comprising an aqueous medium and, dispersed therein, from 0.001 to 4% of a dye compound of Formula (1): A-N=N-D-N=N-E Formula (1) wherein...

3-Isochromanone is prepared by reacting an o-xylene-α,α'-dihalide with carbon monoxide and water in the presence of a catalyst, characterized in that the pH of the reaction is maintained between 7 and 11.

A process for colouring a textile material of aromatic polyester fibre or fibre blend thereof comprises applying to the textile material a dispersion comprising an aqueous medium and, dispersed therein, from 0.001 to 4% of a dye compound of Formula (1) or (2):

A process for preparing a disazo dye compound which is free from water solubilizing groups and is of Formulawherein:A, D and E each independently is an optionallysubstituted heterocyclic or carbocyclic group and atleast one of A, D or E carries directly at least one -SO2Fgro...