Subject of the invention is a method for the production of a carnitine granulate, comprising the steps of (a) providing an aqueous solution comprising at least 65% (w/w) carnitine, (b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 µm, and (c) mixing t...

An isolated and/or artificial pG1 x promoter which is a functional variant of the carbon source regulatable pG1 promoter of Pichia pastoris identified by SEQ ID 1 which pG1 x promoter consists of or comprises at least a part of SEQ ID 1 with a length of at least 293 bp characterized by the following promoter regions...

The tertiary alcohol α-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy- 1-methylethyl)benzenepropanol, the (αS)-enantioner of which is an intermediate in the production of montelukast, is produced by reacting the novel lactone of formula (II) with a methylmagnesium halide in an ethereal solvent in the...

The present invention relates to a process for the selective preparation of acetaldehyde, characterized in that acrolein and one or more ammonium salts dissolved in water are reacted continuously under high pressures and at temperatures of 300-400 °C

The present invention relates to a process for the selective preparation of 3-methylpyridine, characterized in that acrolein and one or more ammonium salt(s) dissolved in water are reacted continuously under high pressures and at temperatures of 200-400°C.

An isolated nucleic acid encoding a leader which has a specific sequence an isolated leader peptide encoded by such nucleic acid an expression cassette comprising such nucleic acid encoding a leader operably linked to a nucleic acid sequence encoding a POI a recombinant yeast host cell or a vector comprising such ex...

Subject of the invention is a method for the production of a cyanopyridine, wherein (A) a gaseous reaction product comprising the cyanopyridine is produced in a reactor, (B) the gaseous reaction product is quenched with water in a column (2) and a gaseous phase is obtained, which is depleted from at least a portion ...

The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof which is reacted with a cyclisation agent selected from phosgene diphosgene triphosgene and mixtures thereof and in that the reaction is carried out in the presen...

The invention is directed to a process for the preparation of a cyclic carbamate starting with o-aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mix o tures thereof, and in that the reaction carried out in the presence...

The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C- PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being co...

Disclosed are halogenated diethyltoluenediamines of formula I wherein either R is an amino group and R is chlorine or bromine or R is an amino group and R is chlorine or bromine and isomeric mixtures thereof. The halogenated diethyltoluenediamines of formula I are useful as chain extenders for polyurethanes and hard...

The invention provides a method for preparing a fiber reinforced part based on cyanate ester or a cyanate ester/epoxy blend comprising the steps of (i) providing a liquid mixture comprising (a) from 15 to 99.9 wt.% of at least one di or polyfunctional cyanate ester (b) from 0 to 84.9 wt.% of at least one di or p...

Subject of the invention is a method for the production of L-carnitine, comprising the steps of (a) providing a solution comprising at least 5% (w/w) carnitine in a first solvent, wherein the carnitine is a mixture of D- and L-carnitine, (b) optionally seeding the solution with L-carnitine crystals, (c) adding an se...

The invention relates to a process for the preparation of ethanedinitrile, by reading hydrocyanic acid in the liquid phase with nitric acid in the presence of a cupric ion catalyst.

Organic dithiopyrophosphates of formula wherein R1, R2, R3, R4 and R5 independently are hydrogen, C1-4 alkyl, chloromethyl or bromomethyl, are prepared in a two-step process from the corresponding 1,3-diols and thiophosphoryl chloride, using 3- methylpyridine both as solvent and as base. ...

The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone its use in perfumes and its use for the preparation of medetomidine.

The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.

The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is ...

Ethynylcyclopropane is prepared in a two-step process by reacting (1,1-dimethoxyethyl)-cyclopropane with a thiol and eliminating the thiol from the intermediate.

The present invention discloses a process for the production of a fatty acid/L-carnitine derivative, whereby the educts are reacted in the presence of monochloroacetic acid.

The invention discloses a method for the preparation of 6- trifluoro-methylpyridine- 3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and or, thoesters (III), and their use for the prepara tion of pharmaceutical, chemical or agrochemical products.

The invention relates to a process for fermentative production of oils comprising polyunsaturated fatty acids (PUFAs) with an altered fatty acid profile from cells of microorganisms from the phylum of the labyrinthulomycota, characterized in that a complexing agent is added to the fermentation medium. ...

Process for purifying an a-keto ester by removing secondary and tertiary alcohols from the a-keto ester. In a first step, the a-keto ester to be purified is treated with a carboxylic anhydride and an acid, which is essentially insoluble under the filtration conditions, to esterify the secondary and tertiary alcohols...

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03....

Subject of the invention is a process for the production of methylbutinol wherein the process comprises at least one pervaporation step. In a preferred embodiment the process comprises the steps of • (a) providing a feed composition comprising methylbutinol and water • (b) subjecting the feed composition to distilla...

A method for the targeted execution of a reaction taking place alongside several competing chemical reactions is described, wherein the speeds of the competing reactions are set by the selection of the reaction conditions in such a way that the desired main reaction is not adversely affected. The invention further d...

The present invention is related to a method for the production of an aldehyde by reducing an ester of a carboxylic acid with H-DIBAL (diisobutylaluminium hydride).

The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid. ...

A process for the preparation of a 2 nitro, 5-chlorOphenylethamic (57)  Abstract  acid alkyeter of general formula IVin which R denotes a branched or unbran ,_ ^ ^^_, atoms, wherein 1,4-chloronitrobenzene of farmula : is reacted with a ohloroethanolo acid alkyl eater oi v^eneral formula III: ...

The invention relates to a method for the obtention of oils, which comprise polyunsaturated fatty acids (PUFAs) and have a modified fatty acid profile, by fermentation from cells of microorganisms of the phylum Labyrinthulomycota, characterized in that a flocculant is added to the fermentation medium. ...

The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is selected from C1-6-alkyl, C3-6-cycloaIkyl and aralkyl, and wherein R2 at each occurrence independently is halogen or C1-6-alkyl, and m is an integer from 0 to 4, Q is selected from halogen, -NO2 and -NR3R4, whe...

A process for the preparation of the compound of formula (I).

The invention is directed to a process for the preparation of a chiral cyclic carbamate of formula (I) and/or mirror image, and/or a salt thereof, from the corresponding o-aminobenzyl alcohol and/or salts thereof.

Subject of the invention is a food composition comprising Lactobacillus  which is capable of aggregating Helicobacter pylori under physiological conditions  and a carrier  wherein the carrier comprises milk serum and wherein the carrier is a product of a fermentation process. Subject of the invention are also method...

Subject of the invention is a method for the production of a cyanopyridine, comprising the steps of (a) providing a column comprising an absorber section and a stripping section, the absorber section being positioned above the stripping section, such that liquid which passed the absorber section enters the stripping...

Subject of the invention is a dehydrogenation catalyst for dehydrogenating methylpiperidine to methylpyridine. Subject of the invention are also methods for preparing the catalysts obtained thereby and methods, in which the catalysts are used.

The present invention discloses a process for the production of 2 methyl 1 4 naphthoquinone and its bisulfite adducts comprising the following steps: a) oxidizing 2 methyl naphthalene (2 MNA) to achieve an organic phase containing 2 methyl naphthoquinone (2 MNQ) and 6 methyl naphthoquinone (6 MNQ); b) subjecting sai...

The invention relaters to a process for the production of an (S) or (R) 4 halo 3 hydroxybutyrate comprising reacting a 4 haloacetoacetate with hydrogen in the presence of a solvent the solvent being a solvent mixture which comprises a first solvent and a second solvent wherein the first solvent is an aliphatic alcoh...

The invention relates to a process for the production of L carnitine tartrate wherein the L carnitine tartrate is precipitated from a reaction mixture comprising L carnitine and tartaric acid dissolved in ethanol the ethanol having a water content of less than 5% (w/w).

A process for the chlorination of alkylanilines is provided allowing a highly selective chlorination in the meta position of the aromatic ring. This is achieved by reacting a mixture comprising the alkylaniline and sulfuric acid with chlorine. This process allows a meta chlorination with a selectivity of more than 9...

A process for the synthesis of chiral propargylic alcohols.

A manufacturing facility for the continuous production of biopharmaceuticals integrated with single-use disposable technology.

The disclosure is directed to a system and method for control of at least one bioreactor other cell cultivation related equipment and systems containing any combination of these in a plant. For example a Plant Wide Control System (PWCS) or a Process Control System (PCS) may be divided into three main components: har...

The invention discloses a method for the preparation of thiophene-2-carbonyl chlorides starting from thiophenes with oxalyl chloride at elevated temperature with short reaction time.

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.

NA

Betaines of formula R3N+-Q-COO- (I), wherein R is C1-4 alkyl and Q is C1-4 alkanediyl, optionally substituted with hydroxy, are prepared in one step by adding an co-halocarboxylate of formula X-Q-COOR' (II), wherein Q is as defined above, R' is Cl1-4 alkyl and X is chlorine, bromine or iodine, to an aqueous solution...

The invention discloses a method for the preparation of octahydrocyclopenta[c]pyrrole, also called 3- azabicyclo[3.3.0]octane, by hydrogenation of 1,2-dicyanocyclo-l-pentene.

The present invention discloses a composition comprising arabinogalactan and polyphenols from larch trees for the use in prophylactic treatment of upper respiratory tract infections.

A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter comprising the steps a) cultivating the cell line with a...

The present invention relates to a process for extraction of a peptide from a reaction mixture resulting from a peptide coupling reaction, the reaction mixture containing the peptide and a polar aprotic solvent selected from the group consisting of A/,A/-dimethylformamide, A/,A/-dimethylacetamide and A/-methyl-2-...

The invention relates to process for the continuous production of 4- chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the pro...

The invention relates to a process for decolorizing a composition comprising a betaine comprising the steps of (a) providing a solution of the composition in an organic solvent, (b) contacting the solution with a decolorant , wherein the decolorant is a polar solid decolorant. The invention also relates to uses of i...

The present invention relates to a process for extraction of a peptide from a reaction mixture resulting from a peptide coupling reaction, the reaction mixture containing the peptide and a polar aprotic solvent selected from the group consisting of N IV-dimethylformamide, iV,iV-dimethylacetamide and iV-methyl-2-pyr...

The present invention discloses a process for the recovery of betaines from electrodialysis (ED) waste streams, whereby said waste streams are treated with a pressure driven membrane process.

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton.

The present invention relates to a process for extraction of a peptide from a reaction mixture resulting from a peptide coupling reaction, the reaction mixture containing the peptide and a polar aprotic solvent selected from the group consisting of N,N-dimethylformamide, A/,A/-dimethylacetamide and A/-methyl-2-pyrr...

The invention relates to the use of L carnitine a salt of L carnitine a derivative of L carnitine and/or salt of a derivative of L carnitine as well as respective methods and 5 compositions for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy ind...

Subject of the invention is a process for the production of L carnitine wherein a ß lactone which is a 4 (halomethyl)oxetane 2 one is converted into L carnitine wherein the process comprises an enzymatic conversion of the ß lactone into (R) 4 halo 3 hydroxybutyric acid or (R) 4 halo 3 hydroxybutyric acid ester. ...

The invention discloses a method for the preparation of tert butyl 6 chloro 3 5 dioxohexanoate from Meldrum s acid derivative and its use for the preparation of tert butyl (4R 6S) (6 hydroxymethyl 2 2 dimethyl 1 3 dioxan 4 yl)acetate(BHA) Rosuvastatin and Atorvastatin.

The invention discloses a method for preparation of 2-(2,3-dimethylphenyl)-l-propanal from bromo 2,3-dimethyl - benzene and aceton, its use in perfumes and its use for the preparation of medetomidine.

The present invention relates to an industrially practicable process for preparing alkali metal and alkaline earth metal tricyanomethanides in a particularly high purity.

The present invention discloses a process for the synthesis of 3-methyl-pyridine from formaldehyde, paracetaldehyde, ammonia and acetic acid, whereby said compounds are reacted and said process comprises the following parameters: a) a reaction temperature of 260-300°C; b) a molar ratio of formaldehyde and paraceta...

The invention discloses a method for the preparation of substituted 4-(heptafluoro-2-propyl) anilines by reaction of 2-bromoheptafluoropropane with anilines in the presence of sodium dithionite, in a solvent and in the presence of a catalyst.

Disclosed herein are methods and compositions useful for detecting and/or quantifying host cell proteins during the production of a product, e.g., a recombinant protein, e.g., an antibody.

A method for producing a recombinant protein of interest (POI) is provided comprising the steps of (a) culturing cells in a cell culture medium to express said POI by adding a feed comprising at least one substrate to said cell culture (b) applying a feeding strategy based on calculating setting and optionally contr...

n+14 mm n 14 n+n+1The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1 2 3 or 4 cyano residues represented by formula (I): [Cat][(ZF(CN))]by a reaction of [(ZF)] with trimethylsilylcyanide in the presence of a Lewis acid and in the presence of the cati...

A liquid laundry detergent composition for clothing characterized by containing a bacteria eliminating active agent at least one type of cationic polymer compound selected from component (a) component (b) and component (c) and a surfactant. The liquid laundry detergent composition for clothing effectively elimi...

The invention discloses a method for preparation of fluoro chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro chloro and fluorochloro alkylation with fluoro chloro and fluorochloroalkyl halides in the presence of di(1 adamantyl) n butylphosphine and in the presence of 2 2 6 6 tetramethylp...

A fluid mixing structure (10) for mixing at least two fluidic components has a flow inlet port and a flow outlet port and comprises a contraction zone (12) an expansion zone (14) and a retention zone (16) arranged in this order in an inflow direction (IFD) of a fluid flow to flow through said fluid mixing structure ...

The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; ...

The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products such as next generation biologics. Modulation of lipid metabolism as described herein includes for example introducing a lipid metabolism modulator described her...

The present disclosure features methods and compositions for increasing the amount of products of cellular metabolism e.g. proteins by lowering the temperature of cells expressing the product at one or more steps while culturing the cells expressing the product and/or recovering the product.

A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell....

Disclosed herein are inter alia methods and compositions useful for detecting and/or quantifying host cell proteins during the production of a product e.g. a recombinant protein e.g. an antibody.

Disclosed herein are methods and compositions useful for evaluating selecting identifying or making a cell or cell line that has improved production capacity for generating higher yields of products and/or improved capacity to produce higher quality products. Products as described herein can include a polypeptide th...

The invention discloses a method for the preparation of 1-methyl-3-(trifluoromethyl)-1H- pyrazol-5-ol with high selectivity with respect to the content of the isomer 1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-ol.

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container a shell at least one agitator at least one sparger at least one gas filter inlet port for the sparger(s) and headspace overlay at least one fill port at least one harvest port at least one sample port and at least one p...

The invention discloses a method for the preparation of 3-(trifluoromethyl)pyrazine-2-carboxylic acid esters starting from alkyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoates by reaction with ethylenediamine.

A eukaryotic host cell engineered to produce a heterologous protein of interest (POI), which cell is genetically modified to reduce production of at least one of three different endogenous host cell protein (HCP), and its use in a method of producing the POI.

Disclosed herein are methods useful for detecting and/or quantifying tropolone in samples, e.g., generated during the production of and in final formulations of a product, e.g., a recombinant protein, e.g., an antibody. Tropolone and derivatives thereof (cycloheptatriene ketones) are separated from a mixture by addi...