A device for use in the control of mechanical forces is provided. The device comprises first and second terminals for connection, in use, to components in a system for controlling mechanical forces and independently moveable. The device further comprises hydraulic means connected between the terminals and containing...
Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described.
...
This invention relates to isolated antibodies which recognise the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis embolism and other conditions mediated by thrombin.
The invention relates to 3-(2",2"-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory disorders.
Provided is a capsule having a shell of material that is a supramolecular cross linked network. The network is formed from a host guest complexation of cucurbituril (the host) and one or more building blocks comprising suitable guest functionality. The complex non covalently crosslinks the building block and/or non ...
A solid material (M1X) (6) comprising a solid solution of a non-metal species (X) in a metal (M1) or a compound between the non-metal species and the metal is immersed in a molten salt (M2Y) (4). The metal (M1) comprises titanium. A cathodic potential is applied to the material to remove a portion of the non-metal s...
The invention relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarker(s) present in a cerebrospmal fluid sample taken from a test subject, said biomarker(s) being selected from the group consisting of: glu...
A method is provided for measuring the viscosity of a fluid sample. The method comprising the steps of: (ii) providing a flow of the fluid sample; (iii) providing a component flow wherein the component flow is a flow of the fluid sample further comprising a tracer component; (iv) generating a laminar flow of the flo...
A photonic device is manufactured by: (i) providing (e.g. by inkjet printing) an aliquot of a liquid crystal material (504); and (ii) depositing the aliquot onto the surface of a flowable material layer (502) to form a liquid crystal deposit the flowable material and the LC material being substantially immiscible. T...
An optical device has a deformable solid substrate and a two dimensional array of metal particles which is carried by the substrate. The array provides a controlled separation between nearest neighbour particles. Deformation of the substrate produces corresponding variation in the controlled separation such that the...
A method for isolating a nucleic acid comprises: binding the nucleic acid to a solid phase at a first pH in the presence of a binding buffer, washing the bound nucleic acid with a wash solution, and eluting the nucleic acid from the solid phase at a second pH which is higher than the first pH. The wash solution comp...
A spin forming process and apparatus is disclosed. A workpiece (e.g. sheet metal) is rotated with respect to a forming roller which bears against one of the outer and inner surfaces of the workpiece to deform the workpiece towards a required shape. First and second support rollers bears against the opposite surface ...
A nanoporous material is disclosed having a plurality of lamellae. Through each lamella is an array of penetrating pores. Adjacent lamellae are spaced apart by an intervening spacing layer. The spacing layer comprises an array of spacing elements integrally formed with and extending between the adjacent lamellae. Th...
The invention provides methods of diagnosing multiple sclerosis (MS) patients, including methods of identifying
multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion,
caused, e.g., by treatment with an anti-CD52 antibody. Also embraced ar...
This invention relates pro coagulant serpin molecules engineered by modification of the P4 P2 P1 and/or P1 residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy for example as pro coagulants for the tr...
The invention provides hydrogel wherein the hydrogel has a supramolecular cross linked network obtainable or obtained from the complexation of an aqueous composition comprising a host such as cucurbituril and one or more polymers having suitable guest functionality. One or more polymers in the aqueous compositio...
The present invention relates to carbon materials comprising carbon nanotubes, powders comprising carbon nanotubes and methods of making carbon nanotubes. In the methods of the present invention, the size and/or formation of floating catalyst particles is closely controlled. The resulting carbon nanotubes typically ...
The invention relates to optical beam steering. There is described an optical beam steering apparatus, comprising: a splitter arranged to split an optical beam into at least a first part having a first polarisation and a second part having a second polarisation, said first and second polarisations being substantiall...
The present invention provides a method for purifying a cucurbituril from a mixture. The method comprises the step of forming a complex between the cucurbituril and a cucurbituril guest. The complex has altered physical and/or chemical properties to the cucurbituril which allow the complex to be separated from at le...
This invention relates to medical devices for labelling a syringe filled from an ampoule and to safer devices for filling a syringe from an ampoule and to associated methods. We describe a device for attaching to an ampoule to label a syringe filled from the ampoule the device comprising: an ampoule mounting portion...
A continuous casting apparatus and method is disclosed for casting a metal strip with a cross sectional form which varies along the length of the strip. The apparatus comprises: opposing cooling means; a molten metal feed system positionable to provide a molten metal feed for solidification between the opposing cool...
This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation significantly increases...
The present, invention relates to liquid crystal compositions having a smectic A structure for
use in an optical device in which the composition is sandwiched between a pair of electrodes
( 12- 15). In essence the composition includes a siloxane oligomer (component (a)) which
may be seen to construct a layered Sm...
Methods are described for determining whether a subject suffering from or suspected of suffering from an infectious disease caused by a microbe is infected with a strain of the microbe that is susceptible to an antimicrobial agent where there exist different strains of the microbe that are resistant to the antimicro...
The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder; wherein z is 1, 2 or 4; X is -CO-Yk-(R1)n or SO2-Yk-(R1)n; k is 0 or 1; Y is a cycl...
Disclosed herein are methods of preventing or treating inflammatory diseases using sulfonamide analogs of 3 aminolactam compounds each with aromatic "tail groups". Compounds as defined by formulae (I) and (I) and the medical uses of the compounds are described herein.
Disclosed herein are methods of preventing or treating inflammatory diseases using 3 aminolactam compounds each with aromatic "tail groups". Compounds as defined by formulae (I) and (I ) and the medical uses of the compounds are described herein.
The invention provides compounds, compositions and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, which are 3-aminocaprolactam derivatives, for the preparation of a medicament intended to treat an inflammatory disorder wherein X is -CO-Y-(R1)n or SO2-Y-(R1)n; and Y is 0 cycloa...
The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors (GPCRs). The library contains compounds of general formula (I) wherein y is any integer from 1 to 8; z is one integer from 0 to 8 with the proviso that y and z...
This invention relates to methods and means for the stimulation of phagocytosis and in particular to the phagocytosis of apoptotic cells, and discloses a role for the protein product of the apoE gene (apolipoproteinE) as a regular of apoptotic cell clearance. ApoE mimetics and other compounds which stimulate the cle...
A solid material (M1X) (6) comprising a solid solution of a non-metal species (X) in a metal or semi-metal (M1) or a compound between the non-metal species and the metal or semi-metal is immersed in a molten salt (M2Y) (4). A cathodic potential is applied to the material to remove a portion of the non-metal species ...
The present invention describes a method of recycling lead from lead containing waste, the method comprising the steps of mixing the battery paste with aqueous citric acid solution so as to generate lead citrate; isolating lead citrate from the aqueous solution; and converting the lead citrate to lead and/or lead ox...
Disclosed is a computer implemented method of interrogating volumetric data, the method including the steps of: defining a reference surface relative to the volumetric data; providing an interrogation window lying in a movable interrogation plane intersecting the reference surface and the interrogation window inters...
A viewing device comprises: a pair of optically aligned lenses which are
moveable relative to each other to vary the gap between facing surfaces of
the lenses, and a linkage for controlling the relative motion. The linkage
includes first and second elongate members which crossover each other at a
crossover pivot...
A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorg...
A sensor which comprises a support medium and a hologram disposed
therein, wherein an optical characteristic of the medium varies as
a result of a change of a property of the medium, and wherein the medium
is heterogeneous such that the change of property is heterogeneous.
A sensing method, which comprises
Subjecting a holographic sensor to an
external physical interaction to which the
sensor is sensitive, and observing a
change in the holographic image.
The present invention" provides extrusion-processable materials having a plurality of capillary channels therethrough, and apparatus and methods for manufacturing such materials. The capillaries may be occupied by gases, liquids or other phases. The materials may be anisotropic foams which have high voidage. The met...
A method for the detection of an analyte in a fluid, which comprises contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring th...
A stimulated or non-stimulated T-cell sample can be used to diagnose or monitor a psychotic disorder, to identify a biomarker, or as to test a considerate as a potential therapeutic agent.
This invention relates to methods for identifying aggregation-prone regions in structured (folded) proteins and to related methods for determining the aggregation propensity of a protein, to computer program code and equipment for implementing the methods, and to related methods of identifying new drugs and drug tar...
The present invention provides biomarkers for schizophrenic and bipolar disorders and methods of diagnosis, monitoring and screening associated with the biomarkers and kits for performing such methods.
The invention relates to the use of Broad-Spectrum Chemokine Inhibitors (BSCIs), and in particular members of the acylaminolactam class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of inflammatory diseases. In particular, improved compositions consisting of BSCI ag...
The present invention relates to plasma display panel and a method for manufacturing the same. The back glass substrate comprises the plurality of electrodes orthogonal to each other while the front glass substrate is kept free from any kind of structure. The box shaped barrier-rib walls is also formed. The discharg...
" An electrical component comprising a substrate (30) carrying a LC cell (10) wherein the LC cell (10) comprises liquid crystal material (20) containing anistropic particles (25), at least one conductive member (36) disposed on the substrate (30) and at least one conductive member (34) disposed over the LC cell (10)...
Potential therapeutic, agent for the prevention, treatment or amelioration of an affective disorder, such as a bipolar disorder, depression or anxiety disorder are identified. Also provided are methods for diagnosing and monitoring affective disorders. The methods are based on changes in expression of one or more ge...
Methods and means for producing xylan structures xylan structures in plants having a non-native saccharide moiety substitution side chain component, plants and plant cells comprising modified xylan structures, methods of identifying mutant plants comprising xylan structures in plants having a non-native saccharide m...
The invention provides compounds of general formulae I - IV or pharmaceutically acceptable salts thereof:
The invention also provides methods of preparing the compounds, pharmaceutical compositions comprising the compounds and use of the compounds for the preparation of medicaments intended to modulate t...
An epigenetic regulatory polypeptide complex comprises at least a first domain having site-specific DNA binding activity and at least a second domain having an arginine methyltransferase activity, wherein the second domain is capable of methylating an arginine residue located in the tail region of a histone H2A. The...
An epigenetic regulatory polypeptide complex comprises at least a first domain having site-specific DNA binding activity and at least a second domain having an arginine methyltransferase activity, wherein the second domain is capable of methylating an arginine residue located in the tail region of a histone H2A. The...
This invention generally relates to an optical beam steering apparatus and a method of manufacturing an optical beam steering apparatus, and more particularly to an optical add drop multiplexer (OADM) such as a reconfigurable OADM (ROADM) comprising the optical beam steering apparatus. In one embodiment, the apparat...
The invention relates to a method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein
said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asympto -
matic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (...
Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described.
...
Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-inflammatory effects of iC3b. Methods, agents, and compositions for treatment of such diseases are described.
Refere...
An electromagnetic valve comprises a yoke (10); a magnet (30a 30b) having pole pieces (50a 50b) defining a gap; a flexure assembly (40) having one end attached to the yoke such that part of the flexure assembly extends into the gap the flexure assembly having at least one resilient portion formed of a resilient mate...
The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors (GPCRs). The library contains compounds of general formula (I) wherein y is any integer from 1 to 8; z is one integer from 0 to 8 with the proviso that y and z...
A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; a...
The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject
comprising providing a test biological sample from the subject, performing spectral analysis on
said test biological sample to provide one or more spectra, and, comparing the one or more
spectra with one or more control...
The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10) or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical comp...
A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising...
A method for obtaining a liquid from a porous solid phase is described. The method comprises forming a liquid seal at a first end of a porous solid phase to which a liquid is bound wherein liquid of the liquid seal is immiscible with the liquid bound to the solid phase and applying a pressure differential across the...
A method for analysing a component is provided. The method comprises the steps of: (iii) providing the electrophoretic or thermophoretic movement of the component into a second fluid flow; (iv) diverting a part of a first fluid flow a part of the second fluid flow or parts of the first fluid flow and the second flui...
A microfluidic device (11) is provided for separation and analysis of microfluidic samples. The device comprises: a separation channel (10); a first electrolyte channel (12) configured to provide a flow of high conductivity electrolyte solution in use; and provided with a positive electrode (13) at a downstream outl...
An anode active material for a lithium ion battery, or other electrochemical device, is disclosed. The material comprises particles of Fe Al Li O, wherein Fe is present in an amount of at least 10 wt% to at most 90 wt%, Al is present in an amount of at least 0.1 wt% to at most 90 wt%, and Li is optionally present, i...
A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed recrystallized and then the zincblende structure group III-nitride layer i...
In a method for treating carbon nanotube-based material the carbon nanotube-based material is suspended in an oxidative atmosphere. An illumination portion is illuminated with electromagnetic radiation to heat the illumination portion the illumination portion being out of direct contact with any supporting surface. ...
The present invention relates to a stable method for introducing at least one inducible cassette into a cell and permitting controllable transcription from within that inducible cassette. The method may be used for any cell type from any eukaryotic organism but has a particular application in the introduction of ind...
This invention relates to the expansion of primary cholangiocytes in the form of cholangiocyte organoids (COs) using culture conditions in which canonical Wnt signalling is inhibited and non-canonical Wnt/PCP signalling is potentiated. Methods of expanding primary cholangiocytes, expanded populations of cholangiocyt...
A method for porosifying a Ill-nitride material in a semiconductor structure is provided, the semiconductor structure comprising a sub-surface structure of a first Ill-nitride material, having a charge carrier density greater than 5 x 1017 cm-3, beneath a surface layer of a second Ill-nitride material, having a char...
This invention relates to modular proteins that are capable of binding to one or more target molecules. The modular binding proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more binding domains. Each binding domain is lo...
The invention relates to the grafting of perennial monocots such as bananas and oil palms. Processes for the production of such plants are disclosed herein.
The present invention relates to the production of a carbon material (eg a carbon nanomaterial) comprising single-walled carbon nanotubes (SWCNTs) and to the carbon material per se.
A carrier system (100) provides a carrier or carriers (12) for carrying assay samples in an assay. The carrier(s) are secured to a substrate (10) by a release layer (14). The carrier(s) are suitable for receiving an assay sample, and the release layer is configured to release the carrier(s) from the substrate in the...
A method measuring the phase transition characteristics of a macromolecule, the method comprising: generating a stream of micro-droplets comprising at least one constituent, of which one constituent comprises the macromolecule, varying the conditions in the micro- droplets; and measuring the relative concentrations ...
24 21gA method for characterising an amorphous material involves an evaluation of a rate of change with temperature of an interaction of the amorphous material with electromagnetic (EM) radiation. The interaction is at an energy of between 6.6 x 10 J and 6.6 x 10 J which corresponds to EM radiation in the terahert...
The present invention relates to methods of identifying pharmacophores and inhibitors against protein aggregation. The present invention also provides pharmacophores themselves and medical uses of agents in the treatment of Alzheimer"s.
Methods of treatment of complement-mediated disorders in particular disorders associated with over-activity of the complement C3b feedback cycle (for example age-related macular degeneration (AMD)) using gene therapy is described. According to the methods levels of complement Factor I are elevated by administration ...
Methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadly neutralizing immune response, and associated T-cell responses, to a pathogen are described, as well as nucleic acid sequences encoding such polypeptides. Methods for determining whether a broadly neutralizing immune respo...
This invention relates to an RNA trans- splicing molecule (RTM) that targets human endogenous retrovirus (HERV) pre-mRNA. The RTM comprises (i) a binding region specific for a HERV pre-mRNA, (ii) a trans- splicing splice domain and (ill) a coding sequence for a suicide protein. The binding region of the RTM binds to...
This invention relates to a method of producing hepatocytes comprising introducing a set of transcription factors consisting of HNF1A; HNF6; F0XA3; RORc and ERa into a population of IPSCs, and culturing the population, such that hepatocytes are produced. Methods of producing hepatocytes, hepatocytes produced by the ...
The invention relates to a lithium sulfur cell, a method of preparing a lithium sulfur cell, and a battery comprising the lithium sulfur cell. The lithium sulfur cell comprises a working electrode comprising a film comprising stacked layers of a metallic phase transition metal dichalcogenide of formula (I): LiaMX2 w...
The present invention relates to antibody conjugates, and methods of manufacturing the same. In particular, the present invention relates to a conjugate comprising an antibody, a linker and at least one active agent, wherein: the linker connects the at least one active agent(s) to the antibody; ii) the linker is att...
This invention relates to antibodies that bind to and inhibit the activity of glial cell-derived neurotrophic factor family receptor alpha like (GFRAL) protein. The invention also relates to the GDF15-GFRAL signalling pathway as a therapeutic target for states of cachexia and conditions involving reduction in food i...
Provided are compounds of the Formula I, and salts, hydrates and solvates thereof: wherein R1, Q, Ra, Rb, Rc, Rd and Re are each as defined in the specification. The compounds are inhibitors of Casein Kinase 2 alpha (CK2a) and are useful for the treatment and/or prevention of diseases and conditions in which CK2a ac...
The invention provides a ternary complex of a cucurbituril host, such as CB[8], with a first aryl guest and second aryl guest, wherein the first aryl guest is a group within a biomolecule, such as insulin, and the first and second aryl guests are diferent. Also provided is a method of decomplexing the complex, the m...
The invention relates to methods for reducing the level of xenobiotic in an environment by contacting the environment with a composition comprising one or more bacterial strains. The invention also relates to bacterial strains for use in method of reducing the level of xenobiotic in a subject. The invention also rel...
A formed sheet metal structure is manufactured from a sheet metal workpiece (1 101). A main anvil tool (10 110) constrains the first surface (3 103) of the sheet metal workpiece. The workpiece is bent to form a first basal region (50 150) and a second basal region (60 160) with a bend (56 156) between them. A ...
A composition is provided comprising one or more of alpha lead oxide, beta lead oxide, metallic lead, Pb2O3 and Pb3O4, the composition comprising particles comprising sub- particles, the sub-particles having a mean greatest dimension of from 10 to 300nm. Methods of making such a composition are also described.
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