Anti Kit Antibodies And Uses Thereof

Abstract

Provided herein in one aspect are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig like domains (that is D4 and/or D5 domains) polynucleotides comprising nucleotide sequences encoding such antibodies and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity such as ligand induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen as well as methods of treating or managing a KIT associated disorder or disease and methods of diagnosing a KIT associated disorder or disease using the antibodies described herein.

Information

Applicants

Specification

Documents

Orders